# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1176088 | Functional | Antidiabetic activity in db/db mouse assessed as weight gain at 10 to 100 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
2. | ALA1176089 | Functional | Antidiabetic activity in db/db mouse assessed as reduction of plasma glucose level at 100 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
3. | ALA1176090 | Functional | Antidiabetic activity in db/db mouse assessed as reduction of plasma glucose level at 30 mg/kg, po qd for 7 days | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
4. | ALA1176091 | Functional | Antidiabetic activity in db/db mouse assessed as reduction of plasma glucose level at 10 mg/kg, po qd for 7 days | Mus musculus | 2 | ALA1177724 | organism-based format | Scientific Literature | |
5. | ALA1176092 | ADME | Oral bioavailability in mouse at 1 mg/kg | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
6. | ALA1176093 | ADME | AUC in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
7. | ALA1176094 | ADME | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
8. | ALA1176095 | ADME | Volume of distribution in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
9. | ALA1176096 | ADME | Clearance in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA1177724 | organism-based format | Scientific Literature | |
10. | ALA1176097 | ADME | Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in lipid accumulation after 7 days by Oil red O staining | Mus musculus | 2 | ALA1177724 | cell-based format | Scientific Literature | |
11. | ALA1176098 | ADME | Induction of adipogenesis in mouse mature 3T3L1 cells assessed as P2 mRNA expression level after 10 days by Oil red O staining | Mus musculus | 2 | ALA1177724 | cell-based format | Scientific Literature | |
12. | ALA1176099 | Functional | Antagonist activity at rat PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as inhibition of rosiglitazone-induced luciferase activity by transactivation assay | Rattus norvegicus | 1 | ALA1177724 | cell-based format | Scientific Literature | |
13. | ALA1176100 | Functional | Antagonist activity at human PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as inhibition of rosiglitazone-induced luciferase activity by transactivation assay | Homo sapiens | 1 | ALA1177724 | cell-based format | Scientific Literature | |
14. | ALA1176101 | ADME | Induction of adipogenesis in mouse blast 3T3L1 cells assessed as P2 mRNA expression level after 7 days by Oil red O staining | Mus musculus | 2 | ALA1177724 | cell-based format | Scientific Literature | |
15. | ALA1176102 | Functional | Partial agonist activity at rat PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay relative to rosiglitazone | Rattus norvegicus | 1 | ALA1177724 | cell-based format | Scientific Literature | |
16. | ALA1176103 | Functional | Partial agonist activity at mouse PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay relative to rosiglitazone | Mus musculus | 1 | ALA1177724 | cell-based format | Scientific Literature | |
17. | ALA1176104 | Functional | Partial agonist activity at rat PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay | Rattus norvegicus | 1 | ALA1177724 | cell-based format | Scientific Literature | |
18. | ALA1176105 | Physicochemical | Solubility in water | 2 | ALA1177724 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA1176107 | Functional | Partial agonist activity at human PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay relative to rosiglitazone | Homo sapiens | 21 | ALA1177724 | cell-based format | Scientific Literature | |
20. | ALA1176108 | Functional | Partial agonist activity at human PPARgamma-LBD expressed in CHO-K1 cells co-transfected with GAL4 assessed as luciferase activity by transactivation assay | Homo sapiens | 22 | ALA1177724 | cell-based format | Scientific Literature |