# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1176113 | B | Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
2. | ALA1176114 | B | Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells after 90 mins by scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
3. | ALA1176115 | B | Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells after 90 mins by scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
4. | ALA1176118 | F | Agonist activity at alpha4beta2 nicotinic receptor in human SH-EP1 cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting | Homo sapiens | 23 | ALA1177712 | cell-based format | Scientific Literature | |
5. | ALA1176284 | F | Agonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting | Homo sapiens | 23 | ALA1177712 | cell-based format | Scientific Literature | |
6. | ALA1176285 | F | Agonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting | Homo sapiens | 23 | ALA1177712 | cell-based format | Scientific Literature | |
7. | ALA1176286 | F | Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
8. | ALA1176287 | F | Agonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as induction of radiolabeled Rb+ influx at 0.005 to 100 uM by liquid scintillation counting | Homo sapiens | 23 | ALA1177712 | cell-based format | Scientific Literature | |
9. | ALA1176288 | F | Antagonist activity at alpha4beta2 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
10. | ALA1176289 | F | Antagonist activity at alpha4beta4 nicotinic receptor in human SH-EP1 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
11. | ALA1176290 | F | Antagonist activity at alpha-1-beta-1-gamma-delta nicotinic receptor in human TE671 cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting | Homo sapiens | 26 | ALA1177712 | cell-based format | Scientific Literature | |
12. | ALA1176297 | B | Selectivity ratio of IC50 for alpha4beta2 nicotinic receptor in human SH-EP1 cells to IC50 for IC50 for human NET | Homo sapiens | 12 | ALA1177712 | cell-based format | Scientific Literature | |
13. | ALA1176302 | F | Smoke cessation activity in sc dosed ICR mouse assessed as inhibition of nicotine-induced antinociception administered 15 mins before nicotine challenge measured after 5 mins of nicotine infusion by hotplate assay | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
14. | ALA1176303 | F | Smoke cessation activity in sc dosed ICR mouse assessed as inhibition of nicotine-induced antinociception administered 15 mins before nicotine challenge measured after 5 mins of nicotine infusion by tail-flick assay | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
15. | ALA1176304 | F | Smoke cessation activity in sc dosed ICR mouse assessed as inhibition of nicotine-induced increase in locomotor activity administered 15 mins before nicotine challenge measured after 5 mins of nicotine infusion | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
16. | ALA1176305 | F | Smoke cessation activity in sc dosed ICR mouse assessed as inhibition of nicotine-induced hypothermia administered 15 mins before nicotine challenge measured after 30 mins of nicotine infusion | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
17. | ALA1176858 | T | Toxicity in sc dosed ICR mouse assessed occurrence of sedation | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
18. | ALA1176859 | T | Toxicity in sc dosed ICR mouse assessed occurrence of convulsion | Mus musculus | 26 | ALA1177712 | organism-based format | Scientific Literature | |
19. | ALA1769983 | F | Antagonist activity at human alpha3beta4 nAChR in HEK293 cells assessed as inhibition of carbamylcholine-induced radiolabeled Rb ion efflux | Homo sapiens | 9 | ALA1764988 | cell-based format | Scientific Literature | |
20. | ALA1769984 | B | Inhibition of human DAT in HEK293 cells assessed as inhibition of [3H]dopamine uptake | Homo sapiens | 9 | ALA1764988 | cell-based format | Scientific Literature |