PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)
Antitussive activity against citric acid-induced cough in Cavia porcellus albino (guinea pig) model assessed as increase in cough latency at 5 to 20 mg/kg, ip administered 30 min before aersol of citric acid for 10 min
Antitussive activity against citric acid-induced cough in Cavia porcellus albino (guinea pig) model assessed as decrease in cough frequency per 10 min at 5 to 20 mg/kg, ip administered 30 min before aersol of citric acid for 10 min
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as reduction in eosinophil count in BAL at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as cough latency at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 4.75 +/- 0.86 min)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as cough latency at 10 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 4.75 +/- 0.86 min)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as decrease in nitrate/nitrite level in per gram of lung tissue at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 by griess assay (Rvb = 195.55 +/- 8.34 umol/g)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as decrease in nitrate/nitrite level in BAL at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 by griess assay (Rvb = 70.16 +/- 6.20 umol/ml)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as increase in GSH level in per gram of lung tissue at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 15.175 +/- 1.809 umol/g)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as increase in GSH level in BAL at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 28.95 +/- 3.66 umol/ml)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as reduction in TBARS level in in per gram of lung tissue at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 0.291 +/- 0.039 nmol/g)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as reduction in TBARS level in BAL at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7 (Rvb = 0.471 +/- 0.08 nmol/ml)
Antiasthmatic activity in Cavia porcellus Hartley (guinea pig) ovalbumin-induced hyperresponsive model assessed as reduction in total lymphocyte count in BAL at 20 mg/kg, ip qd administered for 7 days challenged 30 min post last dose on day 7