# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2384320 | A | Cytotoxicity against human HepG2 cells after 48 hrs by Alamar Blue assay | Homo sapiens | 20 | ALA2380285 | cell-based format | Scientific Literature | |
2. | ALA2384321 | F | Inhibition of heme crystallization to hemozoin | 20 | ALA2380285 | assay format | Scientific Literature | ||
3. | ALA2384322 | B | Binding affinity to hematin (unknown origin) by UV-visible titration analysis | Not specified | 20 | ALA2380285 | assay format | Scientific Literature | |
4. | ALA2384324 | F | Antiplasmodial activity against ring stage Plasmodium falciparum W2 infected in human RBC after 48 hrs by FACS analysis | Plasmodium falciparum | 16 | ALA2380285 | organism-based format | Scientific Literature | |
5. | ALA2384325 | F | Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells co-expressing GFP-Luccon treated for 1 hr prior to infection followed by 24 hrs after compound washout measured after 48 hrs post-infection by Alamar Blue assay | Plasmodium berghei | 20 | ALA2380285 | organism-based format | Scientific Literature | |
6. | ALA3862239 | F | Antimalarial activity against liver stage of Plasmodium berghei ANKA | Plasmodium berghei | 2 | ALA3861949 | assay format | Scientific Literature | |
7. | ALA4303805 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | ALA4303101 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
8. | ALA4403510 | F | Antiparasitic activity against Toxoplasma gondii | Toxoplasma gondii | 26 | ALA4402536 | organism-based format | Scientific Literature | |
9. | ALA4403851 | B | Binding affinity to Salmonella enterica Threonyl-tRNA synthetase assessed as change in melting temperature at 0.5 mM incubated for 10 mins by SYPRO orange dye-based thermal shift assay | Salmonella enterica | 28 | ALA4402548 | assay format | Scientific Literature | |
10. | ALA4403852 | B | Inhibition of Salmonella enterica Threonyl-tRNA synthetase assessed as reduction in aminoacylation activity at 100 uM using L-threonine as substrate incubated for 3 hrs by Kinase-glo luminescence assay relative to control | Salmonella enterica | 28 | ALA4402548 | assay format | Scientific Literature | |
11. | ALA4403853 | B | Inhibition of Salmonella enterica Threonyl-tRNA synthetase assessed as reduction in aminoacylation activity using L-threonine as substrate in presence of incubated for 3 hrs by Kinase-glo luminescence assay | Salmonella enterica | 28 | ALA4402548 | assay format | Scientific Literature | |
12. | ALA4403855 | F | Antibacterial activity against Staphylococcus aureus ATCC 29213 by visual method | Staphylococcus aureus | 6 | ALA4402548 | organism-based format | Scientific Literature | |
13. | ALA4403856 | F | Antibacterial activity against methicillin-resistant Staphylococcus aureus R3708 by visual method | Staphylococcus aureus | 6 | ALA4402548 | organism-based format | Scientific Literature | |
14. | ALA4403857 | F | Antibacterial activity against Enterococcus faecalis ATCC 29212 by visual method | Enterococcus faecalis | 6 | ALA4402548 | organism-based format | Scientific Literature | |
15. | ALA4403858 | F | Antibacterial activity against Escherichia coli ATCC 25922 by visual method | Escherichia coli | 6 | ALA4402548 | organism-based format | Scientific Literature | |
16. | ALA4403859 | F | Antibacterial activity against Salmonella enterica 87 by visual method | Salmonella enterica | 6 | ALA4402548 | organism-based format | Scientific Literature | |
17. | ALA4403860 | F | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by visual method | Pseudomonas aeruginosa | 6 | ALA4402548 | organism-based format | Scientific Literature | |
18. | ALA4495582 | F | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
19. | ALA4513082 | F | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
20. | ALA4711266 | B | Binding affinity to Salmonella enterica Threonyl-tRNA synthetase assessed as change in melting temperature at 0.5 mM incubated for 10 mins by SYPRO orange dye-based thermal shift assay | Salmonella enterica | 13 | ALA4706597 | assay format | Scientific Literature |