Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in oocyst shedding at 5 mg/kg/day, po for 4 days treated 3 days postinfection
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in oocyst shedding at 12.5 mg/kg/day, po for 4 days treated 3 days postinfection
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in oocyst shedding at 5 mg/kg/day, po for 6 days treated 3 days postinfection
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in trophozoites in ileum at 5 mg/kg/day, po for 6 days by hematoxylin and eosin staining
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in trophozoites in appendix at 5 mg/kg/day, po for 6 days by hematoxylin and eosin staining
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in trophozoites in colon at 5 mg/kg/day, po for 6 days by hematoxylin and eosin staining
Antimicrobial activity against Cryptosporidium parvum infected in neonatal BALB/C mouse assessed as reduction in number of trophozoites at 5 mg/kg/day, po for 6 days
Inhibition of Wnt3a activated Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase preincubated with cells followed by Wnt3a addition and measured after 24 hrs by luciferase reporter gene assay
Inhibition of Wnt/beta-Catenin signaling (unknown origin) expressed in recombinant human Wnt-3a-induced Wnt-HEK293 cells incubated for 24 hrs by luciferase reporter gene assay
Inhibition of Wnt/beta-Catenin signaling (unknown origin) expressed in recombinant human Wnt-3a-induced Wnt-HEK293 cells assessed as increase in beta-catenin degradation at 1 uM by Western blot analysis
Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ at 6.5 or 26.5 uM incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay relative to control
Inhibition of His-tagged human recombinant SHMT2 expressed in Escherichia coli BLR(DE3) assessed as reduction in NADPH level using L-serine, THF and NADP+ incubated for 5 mins by SHMT2-MTHFD coupled reaction based fluorescence assay
Inhibition of C-Myc/DDK-tagged human recombinant SYNJ2 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay
Inhibition of C-Myc/DDK-tagged human recombinant SYNJ1 expressed in HEK293T cells assessed as reduction in 5'-phosphatase activity incubated for 8 mins using fluorescently-labeled PI(3,4)P2 probe and Tapp1 PH-domain as detector protein by fluorescence polarization competitive assay