# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA633673 | A | Plasma half life was determined in pigs | Sus scrofa | 10 | ALA1133591 | organism-based format | Scientific Literature | |
2. | ALA677178 | B | Potency measured using recombinant human GLP-1 receptor expressed in Baby Hamster Kidney (BHK)cells | 36 | ALA1133591 | cell-based format | Scientific Literature | ||
3. | ALA940048 | F | Agonist activity at human GLP1 receptor expressed in BHK cells assessed as cAMP accumulation | Homo sapiens | 3 | ALA1147050 | cell-based format | Scientific Literature | |
4. | ALA940145 | F | Antagonist activity at human glucagon receptor assessed as forskolin-induced cAMP production | Homo sapiens | 2 | ALA1147050 | assay format | Scientific Literature | |
5. | ALA940146 | F | Induction of 10 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 100 nM | Mus musculus | 2 | ALA1147050 | assay format | Scientific Literature | |
6. | ALA940148 | F | Induction of 10 mM glucose-induced insulin release in CD1 GLP1 receptor knockout mouse pancreatic islets at 100 nM | Mus musculus | 2 | ALA1147050 | assay format | Scientific Literature | |
7. | ALA940149 | F | Induction of 10 mM glucose-induced insulin release in CD1 GLP1 receptor knockout mouse pancreatic islets at 1000 nM | Mus musculus | 2 | ALA1147050 | assay format | Scientific Literature | |
8. | ALA940150 | F | Induction of 3 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 100 nM | Mus musculus | 2 | ALA1147050 | assay format | Scientific Literature | |
9. | ALA940151 | F | Induction of 3 mM glucose-induced insulin release in CD1 wild type mouse pancreatic islets at 1000 nM | Mus musculus | 2 | ALA1147050 | assay format | Scientific Literature | |
10. | ALA940153 | B | Binding affinity to human GLP1 receptor expressed in BHK cells | Homo sapiens | 1 | ALA1147050 | cell-based format | Scientific Literature | |
11. | ALA3106156 | F | Induction of 8 mM glucose-induced insulin secretion in Han Wistar rat pancreatic islets after 2 hrs by HTRF assay | Rattus norvegicus | 2 | ALA3102798 | assay format | Scientific Literature | |
12. | ALA3620279 | B | Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin | Homo sapiens | 47 | ALA3616405 | cell-based format | Scientific Literature | |
13. | ALA3620280 | B | Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin | Homo sapiens | 47 | ALA3616405 | cell-based format | Scientific Literature | |
14. | ALA3620281 | B | Ratio of IC50 for human GLP1 receptor expressed in BHK cells in presence of 2% human serum albumin to IC50 for human GLP1 receptor expressed in BHK cells in absence of human serum albumin | Homo sapiens | 47 | ALA3616405 | cell-based format | Scientific Literature | |
15. | ALA3620282 | F | Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum albumin | Homo sapiens | 47 | ALA3616405 | cell-based format | Scientific Literature | |
16. | ALA4132517 | F | Body weight lowering effect in ICR mouse assessed as cumulative changes in body weight at 1000 nmol/kg, ip administered every other day for 2 weeks | Mus musculus | 12 | ALA4130377 | organism-based format | Scientific Literature | |
17. | ALA4132519 | F | Agonist activity at full length human GLP1R expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay | Homo sapiens | 28 | ALA4130377 | cell-based format | Scientific Literature | |
18. | ALA4132520 | F | Agonist activity at human GCGR expressed in HEK293 cells assessed as increase in cAMP accumulation after 20 mins by HTRF assay | Homo sapiens | 28 | ALA4130377 | cell-based format | Scientific Literature | |
19. | ALA4132521 | B | Selectivity ratio of EC50 for full length human GLP1R expressed in HEK293 cells to EC50 for human GCGR expressed in HEK293 cells | Homo sapiens | 28 | ALA4130377 | cell-based format | Scientific Literature | |
20. | ALA4132526 | F | Anorectic activity in overnight fasted ICR mouse assessed as reduction in cumulative food intake at 1000 nmol/kg, ip measured up to 24 hrs post dose | Mus musculus | 15 | ALA4130377 | organism-based format | Scientific Literature |