# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2318663 | A | Fraction unbound in mouse plasma | Mus musculus | 3 | cell-free format | Scientific Literature | ||
2. | ALA2320393 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 7 | microsome format | Scientific Literature | ||
3. | ALA2320395 | A | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | organism-based format | Scientific Literature | ||
4. | ALA2320397 | A | Volume of distribution at steady state in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA2320398 | A | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA2320399 | A | Plasma clearance in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Scientific Literature | ||
7. | ALA2320400 | B | Antagonist activity at mouse TP receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
8. | ALA2320401 | B | Antagonist activity at mouse EP4 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
9. | ALA2320402 | B | Antagonist activity at mouse EP2 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
10. | ALA2320403 | B | Antagonist activity at mouse EP3 receptor | Mus musculus | 15 | single protein format | Scientific Literature | ||
11. | ALA2320404 | F | Antagonist activity at mouse EP1 receptor expressed in CHOK1 cells assessed as inhibition of 17PTPGE2-induced calcium influx | Mus musculus | 14 | cell-based format | Scientific Literature | ||
12. | ALA2320405 | B | Selectivity ratio of IC50 for mouse TP receptor to IC50 for human TP receptor | 1 | assay format | Scientific Literature | |||
13. | ALA4702821 | P | Dissociation constant, acidic pKa of compound measured up to 18 mins by capillary electrophoresis | 31 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA4702822 | A | Apparent permeability in dog MDCKII-LE cells at pH 7.4 | Canis lupus familiaris | 36 | cell-based format | Scientific Literature | ||
15. | ALA4702823 | P | Lipophilicity, log D of the compound at pH 7.4 by by shake flask method | 39 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA4702824 | A | Intrinsic clearance in cryopreserved human hepatocytes at 1 uM measured up to 120 mins by LC-MS/MS analysis | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
17. | ALA4702826 | A | Fraction unbound in cynomolgus monkey plasma | Macaca fascicularis | 35 | cell-free format | Scientific Literature | ||
18. | ALA4702828 | A | Ratio of drug level in cynomolgus monkey blood to plasma administered through iv dosing by LC-MS/MS analysis | Macaca fascicularis | 27 | organism-based format | Scientific Literature | ||
19. | ALA4702829 | A | Ratio of drug level in human blood to plasma administered through iv dosing by LC-MS/MS analysis | Homo sapiens | 31 | organism-based format | Scientific Literature | ||
20. | ALA4702831 | A | Hepatic clearance in cynomolgus monkey at < 1 mg/kg, iv administered as cassette dosing | Macaca fascicularis | 27 | organism-based format | Scientific Literature |