# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1218908 | F | Induction of apoptosis in mouse CT26 cells assessed as reduction of Bcl-xL protein level at 5 to 10 uM after 24 hrs by immunoblotting | Mus musculus | 1 | ALA1212914 | cell-based format | Scientific Literature | |
2. | ALA1218909 | F | Induction of apoptosis in mouse CT26 cells assessed as reduction of Bcl-2 mRNA level at 10 uM after 24 hrs by RT-PCR analysis | Mus musculus | 1 | ALA1212914 | cell-based format | Scientific Literature | |
3. | ALA1218910 | F | Induction of apoptosis in mouse CT26 cells assessed as reduction of Bcl-xL mRNA level at 10 uM after 24 hrs by RT-PCR analysis | Mus musculus | 1 | ALA1212914 | cell-based format | Scientific Literature | |
4. | ALA1218911 | F | Induction of apoptosis in mouse CT26 cells assessed as inhibition of Bcl-2-Bax interaction at 20 uM after 24 hrs by immunoprecipitation analysis | Mus musculus | 1 | ALA1212914 | cell-based format | Scientific Literature | |
5. | ALA1218912 | F | Induction of apoptosis in mouse CT26 cells assessed as inhibition of Bcl-xL-Bim interaction at 20 uM after 24 hrs by immunoprecipitation analysis | Mus musculus | 1 | ALA1212914 | cell-based format | Scientific Literature | |
6. | ALA1218913 | F | Antitumor activity against mouse CT26 cells xenografted in BALB/c mouse assessed as decrease of tumor volume at 10 umol/kg, po for 12 consecutive days | Mus musculus | 1 | ALA1212914 | organism-based format | Scientific Literature | |
7. | ALA1218916 | T | Toxicity in BALB/c mouse assessed as weight loss at 120 umol/kg, po administered daily once for 12 days | Mus musculus | 2 | ALA1212914 | organism-based format | Scientific Literature | |
8. | ALA1218917 | T | Toxicity in BALB/c mouse assessed as induction of small intestine damage at 120 umol/kg, po administered daily once for 12 days | Mus musculus | 2 | ALA1212914 | organism-based format | Scientific Literature | |
9. | ALA1219921 | F | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
10. | ALA1219922 | F | Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
11. | ALA1219923 | F | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
12. | ALA1219924 | F | Cytotoxicity against human SW620 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
13. | ALA1219925 | F | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
14. | ALA1219926 | F | Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay | Mus musculus | 8 | ALA1212914 | cell-based format | Scientific Literature | |
15. | ALA1219927 | F | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | Homo sapiens | 8 | ALA1212914 | cell-based format | Scientific Literature | |
16. | ALA1219928 | F | Cytotoxicity against mouse 4T1 cells after 72 hrs by MTT assay | Mus musculus | 8 | ALA1212914 | cell-based format | Scientific Literature | |
17. | ALA1219929 | F | Cytotoxicity against mouse CT26 cells after 72 hrs by MTT assay | Mus musculus | 8 | ALA1212914 | cell-based format | Scientific Literature | |
18. | ALA1219930 | P | Solubility of the compound in 100 gram of water | 2 | ALA1212914 | small-molecule physicochemical format | Scientific Literature | ||
19. | ALA1219931 | P | Chemical stability of the compound in phosphate buffered saline at pH 7.2 to 7.4 after 30 mins | 1 | ALA1212914 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA1219932 | A | Metabolic stability of the compound in human serum after 30 mins | Homo sapiens | 1 | ALA1212914 | cell-free format | Scientific Literature |