# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1227139 | B | Inhibition of RabGGTase in african green monkey COS7 cells assessed as Rab prenylation up to 50 uM by Western blot analysis | 3 | cell-based format | Scientific Literature | |||
2. | ALA4421916 | B | Inhibition of rat recombinant geranylgeranyltransferase type I expressed in Escherichia coli assessed as reduction in geranylgeranylation of RhoA incubated for 30 mins in presence of [3H]GGPP by scintillation counting assay relative to control | Rattus norvegicus | 87 | assay format | Patent Bioactivity Data | ||
3. | ALA4421918 | B | Inhibition of RabGGTase (unknown origin) using YPTI as substrate protein and [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 9 | protein complex format | Patent Bioactivity Data | ||
4. | ALA4421919 | B | Inhibition of rat recombinant FTase alpha/beta expressed in Escherichia coli using K-Ras4B as a substrate as and [3H]farnesyl pyrophosphate incubated for 30 mins by scintillation counting assay | Rattus norvegicus | 9 | assay format | Patent Bioactivity Data | ||
5. | ALA4421948 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4421965 | B | Inhibition of RabGGTase in HEK293 cells assessed as reduction in geranylgeranylation of Rab5b protein at 5 to 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4421966 | B | Inhibition of geranylgeranyltransferase type I in HEK293 cells expressing Myc-HA-tagged Rheb-WT assessed as effect on unprenylated Rap1 accumulation at 5 to 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4421967 | B | Inhibition of FTase in HEK293 cells assessed as reduction in H-ras farnesylation at 5 to 20 to 10 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4421968 | B | Inhibition of RabGGTase in HEK293 cells assessed as increase in Rab5b protein in soluble fraction at 5 to 20 uM incubated for 48 hrs by SDS-PAGE and immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4421969 | B | Competitive type inhibition of RabGGTase (unknown origin) using varying Rab7 as substrate protein and fixed [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
11. | ALA4421970 | B | Uncompetitive type inhibition of RabGGTase (unknown origin) using fixed Rab7 as substrate protein and varying [3H]geranylgeranyl pyrophosphate incubated for 20 mins by scintillation counting assay | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
12. | ALA5223839 | B | Inhibition of Geranylgeranyl transferase type-2 in human NIH3T3 cells assessed as inhibition of Rab geranylgeranylation incubated for 48 hrs by immunoblotting assay | Homo sapiens | 1 | cell-based format | Scientific Literature |