| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2162663 | F | Activation of Shh pathway in mouse Shh-Light II cells assessed as induction of gli1 expression after 48 hrs by renilla luminescence assay | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA2162665 | A | Cytotoxicity against HUVEC up to 10 uM after 24 hrs by WST-1 assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA2162666 | A | Cytotoxicity against HUVEC after 24 hrs by WST-1 assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA2162668 | B | Activation of Shh pathway in human foreskin fibroblasts assessed as increase in VEGF expression after 48 hrs by ELISA | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 5. | ALA2162669 | B | Activation of Shh pathway in human foreskin fibroblasts assessed as increase in VEGF expression at 0.1 to 1 uM after 48 hrs by ELISA relative to control | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 6. | ALA2162670 | B | Activation of Shh pathway in human foreskin fibroblasts assessed as induction of maximum VEGF expression at 0.5 uM after 48 hrs by ELISA relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA2162672 | F | Induction of HUVEC proliferation after 48 hrs by BrdU-incorporation assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 8. | ALA2162673 | F | Induction of angiogenesis in HUVEC assessed as formation of cell sprouts after 48 hrs by BrdU incorporation assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 9. | ALA1226128 | B | Activation of Shh in ptch1 gene-deficient MEF assessed as beta-galactosidase activity after 30 hrs by chemiluminescence assay in presence of 100 nM 3-keto-N-aminoethyl-N'-aminocaproyldihydrocinnamoyl cyclopamine | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 10. | ALA1246370 | F | Agonist activity at hedgehog receptor | 6 | assay format | Scientific Literature | |||
| 11. | ALA3860329 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA3860330 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 10 uM incubated for 6 days by alkaline phosphatase assay relative to GSA-10 | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3860333 | F | Induction of mouse C3H10T1/2 cell differentiation into osteoblast at 0.3 uM in presence of smo ShRNA incubated for 6 days by alkaline phosphatase assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA3860338 | B | Agonist activity at Smo in mouse NIH/3T3 cells transfected with Gli-dependent firefly luciferase reporter assessed as stimulation of Gli transcription factor incubated for 40 hrs | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA3860339 | B | Agonist activity at Smo in cerebellar granule cell precursors isolated from rat at postnatal day 8 assessed as stimulation of proliferation by [3H]-thymidine incorporation assay | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
| 16. | ALA3860342 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of adenylate cyclase activator forskolin incubated for 6 days by alkaline phosphatase assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3860343 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast at 0.3 uM in presence of phosphodiesterase inhibitor IBMX incubated for 6 days by alkaline phosphatase assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3860345 | B | Induction of Smo translocation to primary cilium in mouse NIH/3T3 cells at 1 uM after overnight incubation by DAPI staining-based immunofluorescence assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3860347 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli1 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3860348 | B | Agonist activity at Smo in mouse C3H10T1/2 cells assessed as effect on Gli2 expression at 1 uM after 48 hrs by RT-PCR method relative to vehicle-treated control | Mus musculus | 1 | cell-based format | Scientific Literature |
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