# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1827810 | B | Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs | Mus musculus | 27 | cell-based format | Scientific Literature | ||
2. | ALA1827811 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-8 release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
3. | ALA1827812 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
4. | ALA1827813 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
5. | ALA1827814 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
6. | ALA1827815 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-8 release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA1827816 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
8. | ALA1827817 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA1827818 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
10. | ALA1827819 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma IL-8 level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
11. | ALA1827820 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma TNFalpha level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
12. | ALA1827821 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma IL-6 level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
13. | ALA1827822 | P | Octanol/water distribution coefficient, log D of the compound at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA1827823 | A | Permeability across apical to basolateral side of MDCK cells expressing MDR1 at 5 uM | Canis lupus familiaris | 1 | cell-based format | Scientific Literature | ||
15. | ALA1827824 | A | Intrinsic clearance in human liver microsomes at 1 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
16. | ALA1827825 | A | Intrinsic clearance in human liver S9 fractions at 1 uM after 60 mins by LC-MS/MS analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
17. | ALA1827965 | A | Intrinsic clearance in rat liver S9 fractions at 1 uM after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | subcellular format | Scientific Literature | ||
18. | ALA1827966 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as probe | Homo sapiens | 1 | microsome format | Scientific Literature | ||
19. | ALA1827967 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as probe | Homo sapiens | 1 | microsome format | Scientific Literature | ||
20. | ALA1827968 | A | Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as probe | Homo sapiens | 1 | microsome format | Scientific Literature |