# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1806083 | B | Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 45 | ALA1800055 | cell-based format | Scientific Literature | |
2. | ALA1806084 | B | Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 45 | ALA1800055 | single protein format | Scientific Literature | |
3. | ALA1806085 | B | Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 29 | ALA1800055 | single protein format | Scientific Literature | |
4. | ALA1806086 | B | Inhibition of human MMP7 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 7 | ALA1800055 | single protein format | Scientific Literature | |
5. | ALA1806087 | B | Inhibition of human MMP8 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 30 | ALA1800055 | single protein format | Scientific Literature | |
6. | ALA1806088 | B | Inhibition of human MMP9 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 41 | ALA1800055 | single protein format | Scientific Literature | |
7. | ALA1806089 | B | Inhibition of human MMP13 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 45 | ALA1800055 | single protein format | Scientific Literature | |
8. | ALA1806090 | B | Inhibition of human MMP14 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assay | Homo sapiens | 40 | ALA1800055 | single protein format | Scientific Literature | |
9. | ALA1806091 | A | Cmax in rat at 10 mg/mL, iv and po | Rattus norvegicus | 7 | ALA1800055 | organism-based format | Scientific Literature | |
10. | ALA1806092 | A | Plasma concentration in rat at 10 mg/mL, iv and po | Rattus norvegicus | 7 | ALA1800055 | organism-based format | Scientific Literature | |
11. | ALA1806093 | A | Half life in rat at 10 mg/mL, iv and po | Rattus norvegicus | 7 | ALA1800055 | organism-based format | Scientific Literature | |
12. | ALA1806094 | A | Oral bioavailability in rat at 10 mg/mL | Rattus norvegicus | 7 | ALA1800055 | organism-based format | Scientific Literature | |
13. | ALA1806105 | F | Ex vivo inhibition of IL-1 and oncostatin M-induced bovine nasal cartilage degradation assessed as release of hydroxproline measured up to 16 days by mass spectrometry | Bos taurus | 3 | ALA1800055 | tissue-based format | Scientific Literature |