# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4262302 | Functional | Antiplasmodial activity against Plasmodium falciparum 3D7 after 3 days by SYBR green1 dye based assay | Plasmodium falciparum | 87 | ALA4261502 | organism-based format | Scientific Literature | |
2. | ALA4262303 | Binding | Inhibition of human G9a using biotinylated peptide H3( 1 to 25 residues) as substrate measured after 15 mins in presence of [3H]-SAM by scintillation proximity assay | Homo sapiens | 77 | ALA4261502 | single protein format | Scientific Literature | |
3. | ALA4262304 | Toxicity | Selectivity ratio of IC50 for human G9a to IC50 for Plasmodium falciparum 3D7 | 71 | ALA4261502 | assay format | Scientific Literature | ||
4. | ALA4262305 | ADME | Cytotoxicity against human HepG2 cells after 3 days by CellTiter blue assay | Homo sapiens | 87 | ALA4261502 | cell-based format | Scientific Literature | |
5. | ALA4262306 | Toxicity | Selectivity ratio of IC50 for human HepG2 cells to IC50 for Plasmodium falciparum 3D7 | 87 | ALA4261502 | assay format | Scientific Literature | ||
6. | ALA4329418 | Binding | Binding affinity to LSD1 (unknown origin) | Homo sapiens | 1 | ALA4325908 | single protein format | Scientific Literature | |
7. | ALA4673548 | Binding | Binding affinity to LSD1/CoREST (unknown origin) expressed in Escherichia coli | Homo sapiens | 3 | ALA4673182 | assay format | Scientific Literature | |
8. | ALA5123803 | Binding | Binding affinity to human LSD1/CoREST assessed as dissociation constant by competitive fluorescence polarization assay | Homo sapiens | 31 | ALA5120862 | protein complex format | Scientific Literature | |
9. | ALA5123804 | Binding | Inhibition of human LSD1/CoREST using histone H3 peptide as substrate by fluorescence polarization assay | Homo sapiens | 13 | ALA5120862 | protein complex format | Scientific Literature | |
10. | ALA5123805 | Binding | Inhibition of G9a (unknown origin) assessed as reduction in substrate methylation using histone H3 and SAM as substrate measured after 15 to 60 mins by microfluidic capillary electrophoresis analysis | Homo sapiens | 31 | ALA5120862 | single protein format | Scientific Literature | |
11. | ALA5123818 | Functional | Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 24 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 9 | ALA5120862 | cell-based format | Scientific Literature | |
12. | ALA5123819 | Functional | Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 9 | ALA5120862 | cell-based format | Scientific Literature | |
13. | ALA5123820 | Functional | Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 144 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 9 | ALA5120862 | cell-based format | Scientific Literature | |
14. | ALA5123825 | Functional | Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth at 0.2 to 2.5 uM incubated for 72 to 144 hrs by trypan blue staining based analysis | Homo sapiens | 4 | ALA5120862 | cell-based format | Scientific Literature | |
15. | ALA5123826 | Binding | Inhibition of LSD1 in human MV4-11 cells assessed as increase in H3K4me2 level at 0.2 to 2.5 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 7 | ALA5120862 | cell-based format | Scientific Literature | |
16. | ALA5123830 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 8 | ALA5120862 | cell-based format | Scientific Literature | |
17. | ALA5123833 | Functional | Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 24 hrs | Homo sapiens | 6 | ALA5120862 | cell-based format | Scientific Literature | |
18. | ALA5123834 | Functional | Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 72 hrs | Homo sapiens | 6 | ALA5120862 | cell-based format | Scientific Literature | |
19. | ALA5123835 | Functional | Antiproliferative activity against human RD cells assessed as inhibition of cell growth incubated for 144 hrs | Homo sapiens | 6 | ALA5120862 | cell-based format | Scientific Literature | |
20. | ALA5123836 | Functional | Antiproliferative activity against human Rh30 cells assessed as inhibition of cell growth incubated for 24 hrs | Homo sapiens | 6 | ALA5120862 | cell-based format | Scientific Literature |