| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2318056 | B | Inhibition of HIV-1 protease I54M mutant using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 2. | ALA2318057 | B | Inhibition of HIV-1 protease I50V mutant using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 3. | ALA2318301 | B | Inhibition of HIV-1 protease D30N mutant using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 4. | ALA2318302 | B | Inhibition of HIV-1 protease R8Q mutant using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 5. | ALA2318303 | B | Inhibition of HIV-1 wildtype protease using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | single protein format | Scientific Literature | ||
| 6. | ALA2318304 | B | Ratio of Ki for HIV-1 protease V82A mutant to Ki for HIV-1 wildtype protease | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 7. | ALA2318305 | B | Ratio of Ki for HIV-1protease I54M mutant to Ki for HIV-1 wildtype protease | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 8. | ALA2318306 | B | Ratio of Ki for HIV-1 protease D30N mutant to Ki for HIV-1 wildtype protease | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 9. | ALA2318307 | B | Ratio of Ki for HIV-1 protease I50V mutant to Ki for HIV-1 wildtype protease | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 10. | ALA2318308 | B | Inhibition of HIV-1 protease V82A mutant using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorescence assay | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 11. | ALA2318309 | B | Ratio of Ki for HIV-1 protease R8Q mutant to Ki for HIV-1 wildtype protease | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 12. | ALA2352955 | B | Inhibition of HIV1 protease dimerization transfected in COS7 cells relative to darunavir | Human immunodeficiency virus 1 | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA2352956 | B | Ratio of amprenavir dissociation constant K to compound dissociation constant K for HIV1 protease Q7K, L10F, I13V, I15V, D30V, V32I, L33F, E35D, M36I, S37N, I47V, I54L, Q58E, I62V, L63P, A71V, I84V, N88D, L89T, L90M mutant | Human immunodeficiency virus 1 | 1 | assay format | Scientific Literature | ||
| 14. | ALA2353179 | B | Inhibition of transferrin receptor-fused HIV1 protease Q7K, L10F, I13V, I15V, D30V, V32I, L33F, E35D, M36I, S37N, I47V, I54L, Q58E, I62V, L63P, A71V, I84V, N88D, L89T, L90M mutant autoprocessing expressed in Escherichia coli up to 100 uM by SDS-PAGE analysis | Human immunodeficiency virus 1 | 2 | assay format | Scientific Literature | ||
| 15. | ALA2353181 | B | Binding affinity to HIV1 protease Q7K, L10F, I13V, I15V, D30V, V32I, L33F, E35D, M36I, S37N, I47V, I54L, Q58E, I62V, L63P, A71V, I84V, N88D, L89T, L90M mutant expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetric analysis | Human immunodeficiency virus 1 | 4 | assay format | Scientific Literature | ||
| 16. | ALA2353182 | B | Binding affinity to HIV1 protease Q7K, L10F, I13V, I15V, D30V, V32I, L33F, E35D, M36I, S37N, I47V, I54L, Q58E, I62V, L63P, A71V, I84V, N88D, L89T, L90M mutant expressed in Escherichia coli BL21 (DE3) assessed as association constant by isothermal titration calorimetric analysis | Human immunodeficiency virus 1 | 4 | assay format | Scientific Literature | ||
| 17. | ALA2428516 | B | Inhibition of HIV1 protease | Human immunodeficiency virus 1 | 1 | single protein format | Scientific Literature | ||
| 18. | ALA2428517 | F | Antiviral activity against HIV1 LAV | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA5252950 | B | Binding affinity to HIV1 protease assessed as inhibition constant | Human immunodeficiency virus 1 | 20 | single protein format | Scientific Literature | ||
| 20. | ALA5252952 | F | Antiviral activity against wild type HIV1 ERS104pre infected in human PBMC cells assessed as inhibition of virus-induced cytopathic effect measured after 7 days by MTT assay | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature |
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