| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5252991 | B | Binding affinity to wild-type HIV1 protease expressed in Escherichia coli BL21(DE3) assessed as inhibition constant using (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg peptide as substrate preincubated for 15 mins followed by substrate addition by fluorimeter analysis | Human immunodeficiency virus 1 | 2 | assay format | Scientific Literature | ||
| 2. | ALA5252992 | F | Antiviral activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as protection against virus-induced cytotoxicity incubated for 5 days by XTT assay | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA3227405 | B | Inhibition of HIV1 protease using fluorogenic hexapeptide substrate (2-aminobenzoyl)Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg by fluorimeter | Human immunodeficiency virus 1 | 17 | single protein format | Scientific Literature | ||
| 4. | ALA3227406 | F | Antiviral activity against wild type HIV1 3B infected in human MT2 cells assessed as virus-induced cytopathic effect after 5 days by XTT assay | Human immunodeficiency virus 1 | 18 | organism-based format | Scientific Literature | ||
| 5. | ALA3225577 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease I84V/L90M mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 18 | organism-based format | Scientific Literature | ||
| 6. | ALA3225578 | F | Antiviral activity against wild type HIV1 3B infected in human MT2 cells assessed as fold resistance after 11 months incubation | Human immunodeficiency virus 1 | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA3225579 | F | Antiviral activity against wild type HIV1 3B infected in human MT2 cells assessed as virus-induced cytopathic effect after 5 days by XTT assay relative to in the presence of 50% pooled human serum | Human immunodeficiency virus 1 | 8 | organism-based format | Scientific Literature | ||
| 8. | ALA3225580 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease M46I/I50V mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 17 | organism-based format | Scientific Literature | ||
| 9. | ALA3225581 | A | Cytotoxicity against human MT2 cells assessed as reduction in cell viability after 5 days by XTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA3225582 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 5 days by XTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 11. | ALA3225583 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease G48V/I54V/V82S mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature | ||
| 12. | ALA3225584 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease M46I/V82T/L90M mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature | ||
| 13. | ALA3225585 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease D30N/54V/L90M mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature | ||
| 14. | ALA3225586 | F | Fold resistance, ratio of EC50 for HIV1 3B harboring protease G48V/V82A/I84V/L90M mutant infected in human MT2 cells to EC50 for wild type HIV1 3B infected in human MT2 cells | Human immunodeficiency virus 1 | 10 | organism-based format | Scientific Literature | ||
| 15. | ALA3225587 | A | Clearance in Beagle dog at 2 mg/kg, iv over 30 mins | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA3225588 | A | Oral bioavailability in Beagle dog at 10 mg/kg | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA3225589 | A | Oral bioavailability in Beagle dog at 10 mg/kg in presence of 10 mg/kg COBI | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA3225590 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 19. | ALA3225592 | A | Intrinsic clearance in human liver microsomes in presence of 1 uM RTV | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 20. | ALA3225593 | A | Intrinsic clearance in human liver microsomes in presence of 1 uM COBI | Homo sapiens | 4 | assay format | Scientific Literature |
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