| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1660231 | F | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as host survival days at 0.5 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 21 | organism-based format | Scientific Literature | ||
| 2. | ALA1660236 | F | Antimicrobial activity against Trypanosoma evansi STIB 806K infected in NMRI mouse assessed as complete cure from microbial infection at 0.5 mg/kg, ip administered 3 to 6 days after infection for 4 consecutive days | Trypanosoma evansi | 14 | organism-based format | Scientific Literature | ||
| 3. | ALA4814081 | F | Cytotoxicity against mouse MigA9 cells harboring mouse Hoxa9 gene incubated for 72 hrs by MTS assay | Mus musculus | 10 | cell-based format | Scientific Literature | ||
| 4. | ALA4814083 | B | Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to DNA Hoxa9-binding site (5'-biotin-cctctcctctcctGCGATGATTTACGACCGC) (unknown origin) assessed as Hoxa9/DNA remaining complexes at 5 to 10 uM incubated for 20 mins with DNA followed by compound wash out and subsequent HOXA9 addition and measured after 1 hr by ELISA | 39 | subcellular format | Scientific Literature | |||
| 5. | ALA4814084 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTA/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) at 0.5 uM by spectrophotometric method | 4 | nucleic acid format | Scientific Literature | |||
| 6. | ALA4814085 | B | Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as HOXA9/DNA inhibition at 2.5 uM incubated for 20 mins by electrophoretic mobility shift assay relative to control | 5 | subcellular format | Scientific Literature | |||
| 7. | ALA4814089 | B | Inhibition of HMG-D100 (unknown origin) expressed in reticulocyte lysate system binding to 32P-radiolabeled 117 bp1 DNA fragment (unknown origin) assessed as HMG-D100/DNA inhibition at 2.5 to 5 uM incubated for 20 mins by electrophoretic mobility shift assay relative to control | 2 | subcellular format | Scientific Literature | |||
| 8. | ALA4814090 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTA/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) at 1 uM by spectrophotometric method | 5 | nucleic acid format | Scientific Literature | |||
| 9. | ALA4814092 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as compound-DNA complex formation at 1 to 10 uM at wavelength of 300 to 400 nM by circular dichroism method | Not specified | 9 | nucleic acid format | Scientific Literature | ||
| 10. | ALA4814093 | B | Binding affinity to DNA Hoxa9-binding site (strand a-CTGCGATGATTTACGACCGC/strand b-GCGGTCGTAAATCATCGCAG) (unknown origin) assessed as change in positive ellipticity band of the DNA helix at 1 to 10 uM at wavelength of 300 to 400 nM by circular dichroism method | Not specified | 9 | nucleic acid format | Scientific Literature | ||
| 11. | ALA4814094 | B | Binding affinity to DNA FP-Hoxa9 binding site-1R (strand a-cgcgGTTCCTCTGATCGCGGACCACCGACAGCTGCGATGATTTACGACCGCGCTCGAACCTGAACCTGATCTCAAGTGCT/strand b-ctagAGCACTTGAGATCAGGTTCAGGTTCGAGCGCGGTCGTAAATCATCGCAGCTGTCGGTGGTCCGCGATCAGAGGAAC) (unknown origin) assessed as recognition of HOXA9 binding site 5'-ATTTA at 0.1 to 1 uM by DNase1footprinting based densitometric analysis | Not specified | 4 | nucleic acid format | Scientific Literature | ||
| 12. | ALA4814096 | B | Binding affinity to DNA Hoxa9 binding site-5'ATGA mutant (strand a-CTGCGTAGATTTACGACCGC/strand b-GCGGTCGTAAATCTACGCAG) (unknown origin) by UV/visible spectrophotometric method | Not specified | 3 | nucleic acid format | Scientific Literature | ||
| 13. | ALA4814097 | B | Binding affinity to DNA Hoxa9 binding site-5'-ATTTA mutant (strand a-CTGCGATGAGTCACGACCGC/strand b-GCGGTCGTGACTCATCGCAG) (unknown origin) assessed as decrease in deltaTm by UV/visible spectrophotometric method relative to wild type HBS | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 14. | ALA4814098 | B | Binding affinity to DNA Hoxa9-binding site-5'-ATTTA/5'ATGA double mutant (strand a-CTGCGTAGCGTCACGACCGC/strand b-GCGGTCGTGACGCTACGCAG) (unknown origin) assessed as decrease in deltaTm by UV/visible spectrophotometric method relative to wild type HBS | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 15. | ALA4814101 | B | Binding affinity to DNA FP-Hoxa9-binding site-1R mutant (strand a-cgcgGTTCCTCTGATCGCGGACCACCGACAGCTGCGATGCTGTCCGACCGCGCTCGAACCTGAACCTGATCTCAAGTGCT/strand b-ctagAGCACTTGAGATCAGGTTCAGGTTCGAGCGCGGTCGGACAGCATCGCAGCTGTCGGTGGTCCGCGATCAGAGGAAC) (unknown origin) at 0.5 to 1.5 uM by DNase1footprinting based densitometric analysis | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 16. | ALA4814102 | B | Binding affinity to DNA Hoxa9-binding site ATGATTTA (unknown origin) by surface plasmon resonance assay | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 17. | ALA4814103 | B | Binding affinity to hairpin DNA Hoxa9-binding site 5'-biotin-CCATGATTTACCTCTGTAAATCATGG (unknown origin) by surface plasmon resonance | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 18. | ALA4814104 | B | Binding affinity to hairpin DNA HOXA9-binding site mutant 5'-biotin-CCATGACCTACCTCTGTAGGTCATGG (unknown origin) by surface plasmon resonance | Not specified | 2 | nucleic acid format | Scientific Literature | ||
| 19. | ALA4814105 | B | Selectivity ratio of Kd for hairpin DNA HOXA9-binding site mutant 5'-biotin-CCATGACCTACCTCTGTAGGTCATGG to Kd for hairpin DNA HOXA9-binding site 5'-biotin-CCATGATTTACCTCTGTAAATCATGG (unknown origin) | Not specified | 2 | assay format | Scientific Literature | ||
| 20. | ALA4814107 | F | Induction of cell death in mouse MigA9 cells harboring mouse Hoxa9 gene assessed as propidium iodide-positive cells at 15 uM incubated for 24 hrs by propidium iodide staining based flow cytometry (Rvb = 9.06 +/- 0.53%) | Mus musculus | 6 | cell-based format | Scientific Literature |
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