# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3755831 | F | Antitumor activity against human D54MG cells expressing Escherichia coli PNP M64V mutant xenografted in nude mouse assessed as inhibition of tumor growth at 10 and 20 mg/kg, administered via peritoneal cavity 5 times a day (every 2 hrs) for 3 consecutive days measured on day 17 to 19 after tumor implantation | Homo sapiens | 1 | ALA3751814 | organism-based format | Scientific Literature | |
2. | ALA3755832 | A | Terminal half life of compound in mouse at 100 mg/kg, ip by reverse phase HPLC analysis | Mus musculus | 1 | ALA3751814 | organism-based format | Scientific Literature | |
3. | ALA3755834 | A | Prodrug activation assessed as recombinant human PNP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Homo sapiens | 4 | ALA3751814 | single protein format | Scientific Literature | |
4. | ALA3755835 | A | Prodrug activation assessed as recombinant human MTAP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Homo sapiens | 4 | ALA3751814 | single protein format | Scientific Literature | |
5. | ALA3755836 | A | Prodrug activation assessed as recombinant Escherichia coli PNP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Escherichia coli | 6 | ALA3751814 | assay format | Scientific Literature | |
6. | ALA3755837 | A | Prodrug activation assessed as recombinant Escherichia coli PNP M64V mutant-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Escherichia coli | 4 | ALA3751814 | assay format | Scientific Literature | |
7. | ALA3755838 | A | Prodrug activation assessed as recombinant Trichomonas vaginalis PNP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Trichomonas vaginalis | 6 | ALA3751814 | assay format | Scientific Literature | |
8. | ALA3755839 | A | Prodrug activation assessed as recombinant Sulfolobus solfataricus MTAP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Saccharolobus solfataricus | 6 | ALA3751814 | single protein format | Scientific Literature | |
9. | ALA3755981 | A | Prodrug activation assessed as recombinant Escherichia coli SAH/MTA hydrolase-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Escherichia coli | 5 | ALA3751814 | single protein format | Scientific Literature | |
10. | ALA3755982 | A | Prodrug activation assessed as Francisella tularensis PNP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis | Francisella tularensis | 6 | ALA3751814 | assay format | Scientific Literature | |
11. | ALA3755983 | A | Prodrug activation in human D54MG cells expressing Escherichia coli PNP M64V mutant xenografted in nude mouse assessed as Escherichia coli PNP M64V mutant-mediated compound cleavage per mg of tumor tissue at 5-20 mg/kg administered via peritoneal cavity 5 times a day (every 2 hrs) for 3 consecutive days measured on day 17 | Escherichia coli | 1 | ALA3751814 | organism-based format | Scientific Literature | |
12. | ALA3755984 | F | Antitumor activity against human D54MG cells expressing Escherichia coli PNP M64V mutant xenografted in mouse assessed as time for tumor growth delay at maximum tolerated dose | Homo sapiens | 1 | ALA3751814 | cell-based format | Scientific Literature |