# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1243425 | Functional | Enhancement of autophagy in rat PC12 cells assessed as decrease in alpha-synuclein A53T mutant level at 43 uM by immunoblotting | Rattus norvegicus | 3 | ALA1240327 | cell-based format | Scientific Literature | |
2. | ALA1243427 | ADME | Cytotoxicity against african green monkey COS7 cells at 43 uM after 24 hrs by FACS analysis | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
3. | ALA1243429 | Binding | Inhibition of EGFP-tagged huntingtin aggregation expressed in african green monkey COS7 cells at 43 uM after 48 hrs by Western blot analysis | 1 | ALA1240327 | cell-based format | Scientific Literature | ||
4. | ALA1243431 | Binding | Inhibition of EGFP-tagged huntingtin expressed in african green monkey COS7 cells assessed as protection against protein-induced cell death at 43 uM after 48 hrs Western blot analysis | 1 | ALA1240327 | cell-based format | Scientific Literature | ||
5. | ALA1243432 | Binding | Inhibition of EGFP-tagged huntingtin aggregation in MEF harboring Atg5 gene at 47 uM after 48 hrs by Western blot analysis | Mus musculus | 3 | ALA1240327 | single protein format | Scientific Literature | |
6. | ALA1243433 | Binding | Inhibition of EGFP-tagged huntingtin aggregation in MEF harboring Atg5 gene at 43 uM after 48 hrs by Western blot analysis | Mus musculus | 1 | ALA1240327 | single protein format | Scientific Literature | |
7. | ALA1243434 | Binding | Inhibition of EGFP-tagged huntingtin aggregation in Atg5-deficient MEF at 47 uM after 48 hrs by Western blot analysis | Mus musculus | 3 | ALA1240327 | single protein format | Scientific Literature | |
8. | ALA1243435 | Binding | Inhibition of EGFP-tagged huntingtin aggregation in Atg5-deficient MEF at 43 uM after 48 hrs by Western blot analysis | Mus musculus | 1 | ALA1240327 | single protein format | Scientific Literature | |
9. | ALA1243437 | Functional | Induction of autophagy in human HeLa cells harboring MAP1LC3 gene at 43 uM after 24 hrs by DAPI staining-based fluorescence microscopy | Homo sapiens | 1 | ALA1240327 | cell-based format | Scientific Literature | |
10. | ALA1243439 | Functional | Increase in MAP1LC3 level in bafilomycin A1-treated human HeLa cells at 43 uM treated fro 24 hrs before bafilomycin A1 challenge by immunoblotting analysis | Homo sapiens | 1 | ALA1240327 | cell-based format | Scientific Literature | |
11. | ALA1243441 | Functional | Neuroprotective activity in Drosophila melanogaster Huntington's disease model harboring huntington protein mutant assessed as protection against neurodegeneration at 200 uM | Drosophila melanogaster | 1 | ALA1240327 | organism-based format | Scientific Literature | |
12. | ALA1243443 | ADME | Toxicity against Drosophila melanogaster Huntington's disease model at 200 uM | Drosophila melanogaster | 1 | ALA1240327 | organism-based format | Scientific Literature | |
13. | ALA1243445 | Binding | Inhibition of mTOR phosphorylation expressed in african green monkey COS7 cells at 43 uM by Western blot analysis | 1 | ALA1240327 | cell-based format | Scientific Literature | ||
14. | ALA1243451 | Functional | Effect on ATg6 level in african green monkey COS7 cells at 43 uM after 24 hrs by immunoblotting | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
15. | ALA1243452 | Functional | Effect on ATg5 level in african green monkey COS7 cells at 43 uM after 24 hrs by immunoblotting | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
16. | ALA1243453 | Functional | Effect on ATg7 level in african green monkey COS7 cells at 43 uM after 24 hrs by immunoblotting | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
17. | ALA1243454 | Functional | Effect on ATg12 level in african green monkey COS7 cells at 43 uM after 24 hrs by immunoblotting | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
18. | ALA1243455 | Functional | Increase in conjugated Atg12-Atg5 level in african green monkey COS7 cells at 43 uM after 24 hrs by immunoblotting | Chlorocebus aethiops | 1 | ALA1240327 | cell-based format | Scientific Literature | |
19. | ALA1243457 | Binding | Inhibition of proteasome activity in human HeLa cells assessed as induction of ubiquitinG76V-EGFP reporter level at 43 uM after 24 hrs by immunoblotting | Homo sapiens | 1 | ALA1240327 | subcellular format | Scientific Literature | |
20. | ALA1243459 | Functional | Enhancement of rapamycin-induced clearance of alpha-synuclein A53T mutant protein in rat PC12 cells at 43 uM after 8 hrs by immunoblotting | Rattus norvegicus | 2 | ALA1240327 | cell-based format | Scientific Literature |