# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1249129 | Functional | Antiproliferative activity against human p53, pRB mutant and estrogen receptor deficient MDA-MB-231 cells after 48 hrs by SRB assay | Homo sapiens | 27 | ALA1240425 | cell-based format | Scientific Literature | |
2. | ALA1249130 | Functional | Antiproliferative activity against human p53+/- MCF7 cells after 48 hrs by SRB assay | Homo sapiens | 27 | ALA1240425 | cell-based format | Scientific Literature | |
3. | ALA1249131 | ADME | Antiproliferative activity against human MCF10A cells after 48 hrs by SRB assay | Homo sapiens | 27 | ALA1240425 | cell-based format | Scientific Literature | |
4. | ALA3999655 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain at 100 uM using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method relative to control | Trypanosoma cruzi | 31 | ALA3997824 | single protein format | Scientific Literature | |
5. | ALA3999656 | Binding | Inhibition of recombinant Trypanosoma brucei rhodesain at 100 uM using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method relative to control | Trypanosoma brucei | 31 | ALA3997824 | assay format | Scientific Literature | |
6. | ALA3999657 | Binding | Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-amidomethylcoumarin as substrate by fluorometric method | Trypanosoma cruzi | 6 | ALA3997824 | single protein format | Scientific Literature | |
7. | ALA3999659 | Binding | Competitive inhibition of recombinant Trypanosoma cruzi cruzain in presence of varying levels of Z-phe-Arg-amidomethylcoumarin substrate by Lineweaver-Burk plot analysis | Trypanosoma cruzi | 1 | ALA3997824 | single protein format | Scientific Literature | |
8. | ALA3999660 | Binding | Inhibition of recombinant human cathepsin S at 100 uM using cbz-val-val-arg-7-amino-4-methylcoumarin as substrate measured for 15 mins by fluorescence assay relative to control | Homo sapiens | 3 | ALA3997824 | single protein format | Scientific Literature | |
9. | ALA3999662 | Binding | Inhibition of recombinant human cathepsin S at 100 uM using cbz-val-val-arg-7-amino-4-methylcoumarin as substrate preincubated for 5 mins followed by substrate addition measured for 15 mins by fluorescence assay relative to control | Homo sapiens | 3 | ALA3997824 | single protein format | Scientific Literature | |
10. | ALA3999664 | Binding | Inhibition of rat cathepsin B at 100 uM using cbz-phe-Arg-amidomethylcoumarin as substrate measured for 15 mins by fluorescence assay relative to control | Rattus norvegicus | 3 | ALA3997824 | single protein format | Scientific Literature | |
11. | ALA3999666 | Binding | Inhibition of rat cathepsin B at 100 uM using cbz-phe-Arg-amidomethylcoumarin as substrate preincubated for 5 mins followed by substrate addition measured for 15 mins by fluorescence assay relative to control | Rattus norvegicus | 3 | ALA3997824 | single protein format | Scientific Literature | |
12. | ALA3999668 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen trypomastigote forms infected in mouse L929 cells after 96 hrs by chlorophenol red-beta-D-galactopyranoside dye based assay | Trypanosoma cruzi | 14 | ALA3997824 | cell-based format | Scientific Literature | |
13. | ALA3999669 | ADME | Cytotoxicity against mouse L929 cells after 96 hrs by alamar blue assay | Mus musculus | 14 | ALA3997824 | cell-based format | Scientific Literature | |
14. | ALA3999670 | Toxicity | Selectivity index, ratio of CC50 for mouse L929 cells to IC50 for Trypanosoma cruzi Tulahuen trypomastigote forms infected in mouse L929 cells | 14 | ALA3997824 | cell-based format | Scientific Literature | ||
15. | ALA5244925 | Binding | Inhibition of Trypanosoma cruzi Cruzain | Trypanosoma cruzi | 23 | ALA5244221 | single protein format | Scientific Literature | |
16. | ALA5244927 | Functional | Antitrypanosomal activity against of Trypanosoma cruzi Y trypomastigotes measured after 48 hrs by giemsa staining based microscopic analysis | Trypanosoma cruzi | 2 | ALA5244221 | organism-based format | Scientific Literature | |
17. | ALA5244937 | Functional | Antitrypanosomal activity against Trypanosoma cruzi assessed as reduction in parasite growth | Trypanosoma cruzi | 29 | ALA5244221 | organism-based format | Scientific Literature |