# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1244053 | ADME | Cytotoxicity against african green monkey BSC1 cells after 24 hrs by celltiter glo assay | Chlorocebus aethiops | 3 | ALA1240337 | cell-based format | Scientific Literature | |
2. | ALA1244054 | Functional | Antiplasmodial activity against Plasmodium falciparum schizont infected in human erythrocytes assessed as inhibition of ring-stage parasite growth at 1 to 50 uM after 24 by propidium iodide staining-based FACS analysis | Plasmodium falciparum | 2 | ALA1240337 | organism-based format | Scientific Literature | |
3. | ALA1244056 | Functional | Antiplasmodial activity against Plasmodium falciparum schizont infected in human erythrocytes assessed as effect on schizont morphology at 1 to 50 uM after 24 by propidium iodide staining-based FACS analysis | Plasmodium falciparum | 2 | ALA1240337 | organism-based format | Scientific Literature | |
4. | ALA1244058 | Functional | Antiplasmodial activity against Plasmodium falciparum schizont infected in human erythrocytes assessed as effect on parasite ring-to-schizont morphology at 1 to 50 uM after 24 by propidium iodide staining-based FACS analysis | Plasmodium falciparum | 2 | ALA1240337 | organism-based format | Scientific Literature | |
5. | ALA1244065 | Functional | Antiplasmodial activity against Plasmodium falciparum infected in human erythrocytes assessed as blockade of parasite-mediated rupture of erythrocytes by Giemsa staining | Plasmodium falciparum | 2 | ALA1240337 | organism-based format | Scientific Literature | |
6. | ALA1244066 | Functional | Antiplasmodial activity against Plasmodium falciparum infected in human erythrocytes assessed as effect on parasite morphology by Giemsa staining | Plasmodium falciparum | 2 | ALA1240337 | organism-based format | Scientific Literature | |
7. | ALA1244067 | Binding | Inhibition of Plasmodium falciparum 3D7 PFD0230c by fluorescence spectrophotometry | Plasmodium falciparum 3D7 | 3 | ALA1240337 | single protein format | Scientific Literature | |
8. | ALA1244068 | Binding | Inhibition of Plasmodium falciparum 3D7 cathepsin C by fluorescence spectrophotometry | Plasmodium falciparum 3D7 | 4 | ALA1240337 | single protein format | Scientific Literature | |
9. | ALA1244069 | Binding | Inhibition of Plasmodium falciparum 3D7 PFL2290w by fluorescence spectrophotometry | Plasmodium falciparum 3D7 | 3 | ALA1240337 | single protein format | Scientific Literature | |
10. | ALA1244070 | Binding | Inhibition of Plasmodium falciparum 3D7 falcipain-3 by fluorescence spectrophotometry | Plasmodium falciparum 3D7 | 3 | ALA1240337 | single protein format | Scientific Literature | |
11. | ALA1244071 | Binding | Inhibition of Plasmodium falciparum 3D7 falcipain-2 by fluorescence spectrophotometry | Plasmodium falciparum | 3 | ALA1240337 | organism-based format | Scientific Literature | |
12. | ALA1244072 | Binding | Inhibition of Plasmodium falciparum 3D7 falcipain-1 by fluorescence spectrophotometry | Plasmodium falciparum 3D7 | 3 | ALA1240337 | single protein format | Scientific Literature | |
13. | ALA3301363 | Physicochemical | ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 | 4,197 | ALA3301361 | small-molecule physicochemical format | AstraZeneca Deposited Data | ||
14. | ALA5236029 | Binding | Inhibition of human Cathepsin C using Z-Arg-Arg-AM as substrate at 3 microM relative to control | Homo sapiens | 3 | ALA5233276 | single protein format | Scientific Literature | |
15. | ALA5236034 | Binding | Inhibition of human Cathepsin C using Gly-Phe-AMC as substrate assessed as kobs/[I] | Homo sapiens | 2 | ALA5233276 | single protein format | Scientific Literature |