# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1250983 | Binding | Blockade of mouse HCN1 expressed in HEK293 cells at 5 uM at -120 f-current amplitude by patch-clamp electrophysiological assay relative to control | Mus musculus | 12 | ALA1250521 | cell-based format | Scientific Literature | |
2. | ALA1250984 | Binding | Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | Mus musculus | 9 | ALA1250521 | cell-based format | Scientific Literature | |
3. | ALA1250985 | Binding | Blockade of human HCN4 expressed in HEK293 cells at 5 uM at -120 f-current amplitude by patch-clamp electrophysiological assay relative to control | Homo sapiens | 12 | ALA1250521 | cell-based format | Scientific Literature | |
4. | ALA1250986 | Binding | Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | Mus musculus | 9 | ALA1250521 | cell-based format | Scientific Literature | |
5. | ALA1250987 | Binding | Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay | Homo sapiens | 9 | ALA1250521 | cell-based format | Scientific Literature | |
6. | ALA1250988 | Binding | Blockade of HCN in guinea pig spontaneously beating atria assessed as reduction of heart rate measured for 15 mins | Cavia porcellus | 9 | ALA1250521 | tissue-based format | Scientific Literature | |
7. | ALA1250991 | Binding | Selectivity ratio of EC50 for mouse HCN1 to EC50 for human HCN4 | 1 | ALA1250521 | assay format | Scientific Literature | ||
8. | ALA1250992 | Binding | Selectivity ratio of EC50 for mouse HCN1 to EC50 for mouse HCN2 | Mus musculus | 1 | ALA1250521 | assay format | Scientific Literature | |
9. | ALA1825380 | Binding | Selectivity for human HCN1 over human HCN4 | Homo sapiens | 17 | ALA1821572 | assay format | Scientific Literature | |
10. | ALA1825381 | Binding | Selectivity for human HCN1 over human HCN2 | Homo sapiens | 1 | ALA1821572 | assay format | Scientific Literature |