# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2161164 | B | Activity of Escherichia coli nitroreductase nfsB assessed as NADH oxidation per mg of protein | Escherichia coli | 21 | assay format | Scientific Literature | ||
2. | ALA2161165 | A | Antiproliferative activity against Chinese hamster V79 cells assessed as reduction in cell number after 72 hrs | Cricetulus griseus | 21 | cell-based format | Scientific Literature | ||
3. | ALA2161166 | F | Antiproliferative activity against Chinese hamster V79 cells transfected with Escherichia coli nitroreductase nfsB assessed as reduction in cell number after 72 hrs | Cricetulus griseus | 21 | cell-based format | Scientific Literature | ||
4. | ALA2161167 | U | Ratio of IC50 for Chinese hamster V79 cells to IC50 for Chinese hamster V79 cells transfected with Escherichia coli nitroreductase nfsB | Cricetulus griseus | 21 | cell-based format | Scientific Literature | ||
5. | ALA2161168 | F | Antiproliferative activity against human SKOV3 cells after 18 hrs assessed as reduction in cell number | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
6. | ALA2161169 | F | Antiproliferative activity against human SKOV3 cells transfected with Escherichia coli nitroreductase nfsB assessed as reduction in cell number after 18 hrs | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
7. | ALA2161170 | F | Ratio of IC50 for human SKOV3 cells to IC50 for human SKOV3 cells transfected with Escherichia coli nitroreductase nfsB | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
8. | ALA2161171 | B | Activity of Trypanosoma brucei NTR assessed as NADH oxidation per mg of protein | Trypanosoma brucei | 21 | assay format | Scientific Literature | ||
9. | ALA2161724 | F | Trypanocidal activity against Trypanosoma cruzi intracellular amastigotes forms assessed as inhibition of parasite growth | Trypanosoma cruzi | 21 | organism-based format | Scientific Literature | ||
10. | ALA2161725 | F | Trypanocidal activity against of Trypanosoma brucei bloodstream trypomastigote forms assessed as inhibition of parasite growth | Trypanosoma brucei | 21 | organism-based format | Scientific Literature | ||
11. | ALA2161726 | F | Trypanocidal activity against Leishmania major promastigote forms infected in sandfly gut assessed as inhibition of parasite growth | Leishmania major | 21 | organism-based format | Scientific Literature | ||
12. | ALA2161727 | F | Antiproliferative activity against human SKOV3 cells with mixed population of 25% NTR(+) cells and 75% NTR(-) cells assessed as bystander effect by measuring mixed population of NTR(+) and NTR (-) cells to produce an IC50 midway on log scale between those in either NTR(+) or NTR(-) cells alone after 18 hrs | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
13. | ALA2161729 | F | Antiproliferative activity against human SKOV3 cells with mixed population of 25% NTR(+) cells and 75% NTR(-) cells assessed as reduction in cell number after 18 hrs | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
14. | ALA1267426 | B | Activity of Trypanosoma brucei NTR assessed as NADH oxidation per mg of protein at 100 uM | Trypanosoma brucei | 6 | assay format | Scientific Literature | ||
15. | ALA1267427 | B | Activity of Trypanosoma brucei NTR assessed as NADH oxidation | Trypanosoma brucei | 6 | assay format | Scientific Literature | ||
16. | ALA1267428 | B | Ratio of Kcat to Km for Trypanosoma brucei NTR | Trypanosoma brucei | 6 | assay format | Scientific Literature | ||
17. | ALA1267429 | F | Antiparasitic activity against Trypanosoma brucei BSF after 3 days by Alamar blue assay | Trypanosoma brucei | 22 | organism-based format | Scientific Literature | ||
18. | ALA1267430 | A | Cytotoxicity against human THP1 cells after 6 days by Alamar blue assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
19. | ALA1267431 | A | Therapeutic index, ratio of IC50 against human THP1 cells to IC50 against Trypanosoma brucei | 22 | cell-based format | Scientific Literature | |||
20. | ALA1267432 | F | Antiparasitic activity against Trypanosoma brucei BSF overexpressing NTR gene after 3 days by Alamar blue assay relative to control | Trypanosoma brucei | 4 | organism-based format | Scientific Literature |