| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1273509 | A | Metabolic stability of the compound in rat plasma assessed as compound degradation after 1 hr | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 2. | ALA1273510 | B | Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy | 17 | single protein format | Scientific Literature | |||
| 3. | ALA1273511 | F | Cytotoxicity against human PC3 cells expressing high level of Bcl-xL after 72 hrs by ATP-LITE assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA1273512 | F | Cytotoxicity against human H460 cells expressing high level of Bcl-2 after 72 hrs by ATP-LITE assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA1273513 | F | Cytotoxicity against human H1299 cells expressing high level of Mcl-1 after 72 hrs by ATP-LITE assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA1273514 | F | Cytotoxicity against human BP3 cells expressing high level of Bfl-1 and Mcl-1 after 72 hrs by annexin V-FITC and propidium iodide staining | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 7. | ALA1273515 | F | Cytotoxicity against human RS4:11 cells expressing high level of Bcl-2 and Bcl-xL after 72 hrs by annexin V-FITC and propidium iodide staining | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 8. | ALA1273516 | B | Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
| 9. | ALA1273517 | B | Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
| 10. | ALA1273518 | B | Displacement of F-BakBH3 from Bfl-1 after 30 mins by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
| 11. | ALA1273519 | B | Displacement of F-BakBH3 from Mcl-1 after 30 mins by fluorescence polarization assay | 12 | single protein format | Scientific Literature | |||
| 12. | ALA1273520 | B | Binding affinity Bcl-xL by isothermal titration calorimetry assay | 12 | single protein format | Scientific Literature | |||
| 13. | ALA1273521 | A | Metabolic stability of the compound in rat plasma after 40 mins | Rattus norvegicus | 8 | cell-free format | Scientific Literature | ||
| 14. | ALA1273522 | A | Metabolic stability of the compound in rat microsomes after 40 mins | Rattus norvegicus | 8 | microsome format | Scientific Literature | ||
| 15. | ALA1273523 | A | Permeability of the compound by PAMPA | 8 | assay format | Scientific Literature | |||
| 16. | ALA1273526 | F | Reduction of spleen weight in ip dosed human Bcl2 expressing B6 transgenic BALB/c mouse administered as single dose after 24 hrs | Mus musculus | 17 | organism-based format | Scientific Literature | ||
| 17. | ALA1273530 | T | Toxicity in human Bcl2 expressing B6 transgenic BALB/c mouse assessed as mortality at 60 umol/kg, ip administered as single dose after 24 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA1273531 | T | Toxicity in human Bcl2 expressing B6 transgenic BALB/c mouse assessed as mortality at 30 umol/kg, ip administered as single dose after 24 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA1273532 | F | Reduction of spleen weight in human Bcl2 expressing B6 transgenic BALB/c mouse at 30 umol/kg, ip administered as single dose after 24 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 20. | ALA1273538 | T | Toxicity in human PPC1 cells xenografted nude mouse assessed as mortality at 25 mg/kg, ip administered weekly 3 times | Mus musculus | 2 | organism-based format | Scientific Literature |
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