| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1614179 | F | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Luminescence-based counterscreen assay to identify cytotoxic compounds. (Class of assay: confirmatory) [Related pubchem assays: 2143 (Summary AID (PME-1 inhibitors)), 2130 (PME-1 inhibitors in singlate), 2174 (LYPLA1 inhibitors in singlate), 2177 (LYPLA2 inhibitors in singlate), 2233 (LYPLA1 inhibitors in triplicate), 2232 (LYPLA2 inhibitors in triplicate), 2171 (PME-1 inhibitors in triplicate), 2291 (PME-1 inhibitors in singlate)] | 2 | assay format | PubChem BioAssays | |||
| 2. | ALA1738413 | U | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Gel-based Activity-Based Protein Profiling (ABPP) IC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID463090, AID463091, AID463124, AID463130, AID463131, AID463132, AID463146, AID463149] Panel member name: PME-1 Assay Panel member description: Inhibition of endogenously expressed PME-1 | 26 | assay format | PubChem BioAssays | |||
| 3. | ALA1738449 | U | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Gel-based Activity-Based Protein Profiling (ABPP) IC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID463090, AID463091, AID463124, AID463130, AID463131, AID463132, AID463146, AID463149] Panel member name: ABPP Assay Panel member description: Inhibition of more than 30 other serine hydrolases (anti-target) | 6 | assay format | PubChem BioAssays | |||
| 4. | ALA1738450 | U | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the protein methylesterase PME-1: Gel-based Activity-Based Protein Profiling (ABPP) IC50. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2130, AID2143, AID2171, AID2174, AID2177, AID2232, AID2233, AID2291, AID463090, AID463091, AID463124, AID463130, AID463131, AID463132, AID463146, AID463149] Panel member name: APEH Assay Panel member description: Inhibition of N-acylaminoacyl-peptide hydrolase (APEH) (anti-target) | 6 | assay format | PubChem BioAssays | |||
| 5. | ALA2209037 | B | Inhibition of PME1 overexpressed in HEK293T cells assessed as increase in methylated PP2A level at 20 uM after 1 hr by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA2209038 | B | Inhibition of PME1 overexpressed in HEK293T cells assessed as reduction in demethylated PP2A level at 20 uM after 1 hr by Western blot analysis relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA2209153 | B | Inhibition of PME1 binding to FP-rhodamine in mouse brain soluble proteome after 45 mins by fluorescence polarization activity-based protein profiling assay | Mus musculus | 11 | tissue-based format | Scientific Literature |
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