# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3436042 | Functional | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
2. | ALA3436043 | Functional | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
3. | ALA3436044 | Functional | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | Leishmania mexicana | 13,179 | ALA3433997 | assay format | St Jude Leishmania Screening | |
4. | ALA652568 | Functional | Growth inhibition of CCRF-CEM human leukemic lymphoblasts | Homo sapiens | 15 | ALA1132921 | cell-based format | Scientific Literature | |
5. | ALA659574 | Functional | Inhibitory concentration of compound was tested against Colon 38 tumor growth cell line | Mus musculus | 5 | ALA1127525 | cell-based format | Scientific Literature | |
6. | ALA662326 | Functional | Inhibitory concentration of compound was tested against Colon 26 Mouse Colorectal Carcinoma on 4 hour exposure | Mus musculus | 4 | ALA1127525 | cell-based format | Scientific Literature | |
7. | ALA660423 | Functional | Inhibitory concentration of compound was tested against Colon 26 tumor growth cell line | Mus musculus | 5 | ALA1127525 | cell-based format | Scientific Literature | |
8. | ALA669355 | Binding | Compound was tested for the inhibition of dihydrofolate reductase in Bovine liver | Bos taurus | 4 | ALA1127525 | assay format | Scientific Literature | |
9. | ALA668094 | Binding | Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase. | 8 | ALA1125907 | single protein format | Scientific Literature | ||
10. | ALA669252 | Binding | Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using DHFR as primary target | 3 | ALA1127804 | cell-based format | Scientific Literature | ||
11. | ALA667180 | Binding | Tested in vitro for relative activity against CCRF-CEM human Leukemic lymphoblast by using DHFR as primary target | 1 | ALA1127804 | cell-based format | Scientific Literature | ||
12. | ALA669645 | Binding | Compound was tested for the inhibition of dihydrofolate reductase in P388 cells | 6 | ALA1127525 | cell-based format | Scientific Literature | ||
13. | ALA667313 | Binding | Binding affinity towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligand | 4 | ALA1124936 | cell-based format | Scientific Literature | ||
14. | ALA667321 | Binding | Concentration inhibiting dihydrofolate reductase derived from L1210 cells | 4 | ALA1124936 | cell-based format | Scientific Literature | ||
15. | ALA667324 | Binding | Inhibition of Dihydrofolate reductase (DHFR) enzyme derived from L1210 cells expressed as Ki (pM) | 7 | ALA1126936 | cell-based format | Scientific Literature | ||
16. | ALA663892 | Functional | Inhibitory activity against dihydrofolate reductase in Lactobacillus casei was determined (glutamate residue 2) | Lacticaseibacillus casei | 3 | ALA1123948 | assay format | Scientific Literature | |
17. | ALA663893 | Functional | Inhibitory activity against dihydrofolate reductase in Lactobacillus casei was determined (glutamate residue 3) | Lacticaseibacillus casei | 3 | ALA1123948 | assay format | Scientific Literature | |
18. | ALA663894 | Functional | Inhibitory activity against dihydrofolate reductase in Lactobacillus casei was determined (glutamate residue 4) | Lacticaseibacillus casei | 3 | ALA1123948 | assay format | Scientific Literature | |
19. | ALA663895 | Functional | Inhibitory activity against dihydrofolate reductase in Lactobacillus casei was determined (glutamate residue 5) | Lacticaseibacillus casei | 3 | ALA1123948 | assay format | Scientific Literature | |
20. | ALA884366 | Functional | Inhibitory activity against dihydrofolate reductase in Lactobacillus casei was determined (glutamate residue 6); No data | Lacticaseibacillus casei | 1 | ALA1123948 | assay format | Scientific Literature |