# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA651111 | B | Percent inhibition of rat benzodiazepine receptor assayed using [3H]-flumazenil radioligand at 10 um concentration | 28 | protein complex format | Scientific Literature | |||
2. | ALA648136 | B | Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane | Rattus norvegicus | 30 | cell membrane format | Scientific Literature | ||
3. | ALA653024 | B | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | Rattus norvegicus | 42 | single protein format | Scientific Literature | ||
4. | ALA653027 | B | Displacement of [3H]flunitrazepam from rat brain GABA-A Benzodiazepine receptor | Rattus norvegicus | 41 | assay format | Scientific Literature | ||
5. | ALA653040 | B | Binding affinity against central benzodiazepine receptor(CBR). | 14 | protein complex format | Scientific Literature | |||
6. | ALA653041 | B | Binding affinity against peripheral benzodiazepine receptor( PBR). | 17 | single protein format | Scientific Literature | |||
7. | ALA911273 | B | Displacement of [3H]PK 11195 from peripheral-type benzodiazepine receptor in rat kidney mitochondrial membranes | Rattus norvegicus | 10 | cell membrane format | Scientific Literature | ||
8. | ALA980957 | B | Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane | Rattus norvegicus | 65 | cell membrane format | Scientific Literature | ||
9. | ALA1292026 | P | Solubility of the compound in 0.1 M phosphate buffer at 600 uM at pH 7.4 after 24 hrs by LC/MS/MS analysis | 98 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA1292034 | P | Solubility of the compound at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA1697722 | A | Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset | 530 | assay format | Scientific Literature | |||
12. | ALA1697730 | A | Human drug-induced liver injury (DILI) modelling dataset from Ekins et al | Homo sapiens | 529 | tissue-based format | Scientific Literature | ||
13. | ALA1909291 | T | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of most concern for DILI | 136 | tissue-based format | Scientific Literature | |||
14. | ALA1909321 | A | Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in LTKB-BD | 73 | tissue-based format | Scientific Literature | |||
15. | ALA1909323 | A | Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data | 148 | tissue-based format | Scientific Literature | |||
16. | ALA2061564 | B | Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay | Rattus norvegicus | 38 | cell membrane format | Scientific Literature | ||
17. | ALA2061566 | B | Displacement of [3H]flumazenil from central benzodiazepine receptor in rat cerebral cortex membranes at 10 uM after 90 mins by competitive binding assay | Rattus norvegicus | 63 | cell membrane format | Scientific Literature | ||
18. | ALA2071962 | A | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
19. | ALA2071963 | A | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature | ||
20. | ALA2071964 | A | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | Homo sapiens | 221 | single protein format | Scientific Literature |