# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3615818 | Binding | Displacement of [3H]raclopride from dopamine D2 receptor in Sprague-Dawley rat striatal membranes after 30 mins | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
2. | ALA3615819 | Binding | Displacement of [3H]epibatidine from immunoimmobilized alpha4beta2 nAChR in Sprague-Dawley rat striatal membranes by liquid scintillation counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
3. | ALA3615820 | Binding | Displacement of [3H]epibatidine from immunoimmobilized alpha6beta2 nAChR in Sprague-Dawley rat striatal membranes by liquid scintillation counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
4. | ALA3615821 | Binding | Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in Sprague-Dawley rat hippocampus membrane homogenates by gamma counting | Rattus norvegicus | 11 | ALA3611999 | assay format | Scientific Literature | |
5. | ALA3615822 | Binding | Binding affinity to alpha4beta2 nAChR (unknown origin) | Homo sapiens | 2 | ALA3611999 | protein complex format | Scientific Literature | |
6. | ALA3615826 | Binding | Antagonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of acetylcholine-induced inward current at holding potential of -70 mV by patch clamp technique | Homo sapiens | 8 | ALA3611999 | cell-based format | Scientific Literature | |
7. | ALA3615923 | Binding | Partial agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as inward current at holding potential of -70 mV by patch clamp technique relative to acetylcholine | Homo sapiens | 8 | ALA3611999 | cell-based format | Scientific Literature | |
8. | ALA3615924 | Binding | Agonist activity at nAChR in Sprague-Dawley rat striatal slices assessed as induction of [3H]-dopamine release | Rattus norvegicus | 4 | ALA3611999 | assay format | Scientific Literature | |
9. | ALA3615925 | Binding | Antagonist activity at nAChR in Sprague-Dawley rat striatal slices assessed as inhibition of nicotine-induced [3H]-dopamine release | Rattus norvegicus | 10 | ALA3611999 | assay format | Scientific Literature | |
10. | ALA3615926 | Binding | Antagonist activity at nAChR in Sprague-Dawley rat striatal slices assessed as inhibition of nicotine-induced [3H]-dopamine release at 10 uM | Rattus norvegicus | 1 | ALA3611999 | assay format | Scientific Literature | |
11. | ALA660501 | Binding | Binding affinity towards blood brain barrier choline transporter at 10 uM using rat brain | 6 | ALA1147512 | tissue-based format | Scientific Literature | ||
12. | ALA784320 | Functional | Inhibitory activity against nAChR mediated nicotine-evoked [3H]DA overflow using rat striatal slices; Not active | Rattus norvegicus | 2 | ALA1147512 | organism-based format | Scientific Literature | |
13. | ALA756011 | Binding | Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranes | Rattus norvegicus | 38 | ALA1135953 | assay format | Scientific Literature | |
14. | ALA751222 | Binding | Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain | Rattus norvegicus | 7 | ALA1147512 | tissue-based format | Scientific Literature | |
15. | ALA749559 | Binding | Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat brain membranes | 38 | ALA1135953 | assay format | Scientific Literature | ||
16. | ALA750741 | Binding | Inhibition of [3H]-MLA binding to Nicotinic acetylcholine receptor alpha-7 in rat brain. | 17 | ALA1147512 | tissue-based format | Scientific Literature |