| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1767807 | Binding | Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake at 50 uM after 60 mins by liquid scintillation counting | Homo sapiens | 42 | ALA1765052 | assay format | Scientific Literature | |
| 2. | ALA1767808 | Binding | Inhibition of human URAT1 expressed in xenopus oocyte assessed as inhibition of [14C]-labelled urate uptake after 60 mins by liquid scintillation counting | Homo sapiens | 42 | ALA1765052 | assay format | Scientific Literature | |
| 3. | ALA1909291 | Toxicity | FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of most concern for DILI | 136 | ALA1909281 | tissue-based format | Scientific Literature | ||
| 4. | ALA1909321 | ADME | Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in LTKB-BD | 73 | ALA1909294 | tissue-based format | Scientific Literature | ||
| 5. | ALA1697778 | ADME | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | Homo sapiens | 944 | ALA1697731 | tissue-based format | Scientific Literature | |
| 6. | ALA1697779 | ADME | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | Rodentia | 944 | ALA1697731 | tissue-based format | Scientific Literature | |
| 7. | ALA1697780 | ADME | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 944 | ALA1697731 | tissue-based format | Scientific Literature | ||
| 8. | ALA1614018 | Functional | PUBCHEM_BIOASSAY: Inhibitors of Bacterial Quorum Sensing Structure Activity Relationship (SAR) Analysis: Dose Response Assay. (Class of assay: confirmatory) [Related pubchem assays: 700, 527 ] | Staphylococcus aureus | 32 | ALA1201862 | organism-based format | PubChem BioAssays | |
| 9. | ALA2339943 | Binding | Inhibition of Staphylococcus aureus AgrC1 | Staphylococcus aureus | 23 | ALA2331293 | assay format | Scientific Literature | |
| 10. | ALA3137722 | Toxicity | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 11. | ALA3137723 | Toxicity | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 12. | ALA3137724 | Toxicity | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is number of references indexed. [column 'AIGUE' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 13. | ALA3137725 | Toxicity | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 14. | ALA3137726 | Toxicity | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 15. | ALA3137727 | Toxicity | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 16. | ALA3137728 | Toxicity | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 17. | ALA3137729 | Toxicity | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 18. | ALA3137730 | Toxicity | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | Homo sapiens | 1,214 | ALA3137667 | assay format | Scientific Literature | |
| 19. | ALA3137731 | Toxicity | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | Homo sapiens | 1,214 | ALA3137667 | tissue-based format | Scientific Literature | |
| 20. | ALA3137732 | Toxicity | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | Homo sapiens | 1,214 | ALA3137667 | assay format | Scientific Literature |
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