| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA634449 | P | Calculated partition coefficient (clogP) | 18 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA648718 | B | Binding affinity to alpha-2 adrenergic receptor by displacement of [3H]clonidine | 16 | protein format | Scientific Literature | |||
| 3. | ALA649636 | B | Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat cortical membranes | Rattus norvegicus | 14 | cell membrane format | Scientific Literature | ||
| 4. | ALA654357 | F | Apparent permeability value through blood-brain barrier was evaluated using bovine brain microvessel endothelial cells (BBMEC) | Bos taurus | 8 | organism-based format | Scientific Literature | ||
| 5. | ALA765516 | B | Inhibition of bovine adrenal Phenylethanolamine N-Methyltransferase | Bos taurus | 14 | single protein format | Scientific Literature | ||
| 6. | ALA764119 | B | Relative affinity for PNMT and alpha2 adrenergic receptors | 11 | assay format | Scientific Literature | |||
| 7. | ALA761982 | B | Ability to inhibit phenylethanolamine N-methyl-transferase (PNMT) | 16 | single protein format | Scientific Literature | |||
| 8. | ALA841701 | B | Selectivity ratio (alpha2/PNMT) | 16 | assay format | Scientific Literature | |||
| 9. | ALA830418 | B | Binding affinity against Human phenylethanolamine N-methyl-transferase | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 10. | ALA838690 | B | Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]clonidine as radioligand | Rattus norvegicus | 6 | tissue-based format | Scientific Literature | ||
| 11. | ALA839603 | B | Binding affinity against human alpha 2A adrenergic receptor in CHO cells using [3H]RX-821002 as radioligand | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 12. | ALA840229 | B | Binding affinity against alpha 2 adrenergic receptor in rat cortex using [3H]clonidine as radioligand | Rattus norvegicus | 9 | tissue-based format | Scientific Literature | ||
| 13. | ALA832167 | B | Selectivity for inhibition of alpha 2 adrenergic receptor to that of phenylethanolamine N-methyl-transferase | 6 | assay format | Scientific Literature | |||
| 14. | ALA895324 | B | Inhibition of wild type human PNMT | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 15. | ALA895325 | B | Inhibition of human PNMT K57A mutant | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 16. | ALA895326 | B | Ratio of Ki for wild type human PNMT to Ki for human PNMT K57 mutant | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 17. | ALA4705014 | B | Competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as inhibition constant using PEA as substrate in presence of 100 uM AdoMet as co-substrate by Sigma-plot analysis | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 18. | ALA4705015 | B | Non-competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli assessed as slope inhibition constant in presence of 5 uM PEA as substrate and AdoMet as co-substrate by Sigma-plot analysis | Homo sapiens | 21 | assay format | Scientific Literature | ||
| 19. | ALA4705016 | B | Displacement of [3H]-clonidine from Sprague-Dawley rat alpha2 adrenergic receptor by radioligand binding assay | Rattus norvegicus | 17 | single protein format | Scientific Literature | ||
| 20. | ALA4705017 | B | Selectivity index, ratio of Ki for alpha2 adrenergic receptor in Sprague-dawley rat to Ki for competitive inhibition of C-terminal hexahistidine tag in human recombinant PNMT expressed in Escherichia coli in presence of PEA as substrate and AdoMet as co-substrate by Sigma-plot analysis | 21 | assay format | Scientific Literature |
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