# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3602078 | Binding | Inhibition of JAK3 in mouse BMDM assessed as inhibition of IL-4 induced STAT6 phosphorylation at 500 nM preincubated for 3 hrs followed by IL-4 induction measured after 30 mins by immunoblotting | Mus musculus | 3 | ALA3600288 | single protein format | Scientific Literature | |
2. | ALA3602082 | Binding | Inhibition of JAK3 in mouse BMDM assessed as inhibition of IL-4 induced STAT6 phosphorylation at 10 uM incubated for 3 hrs prior to compound washout for 8 to 24 hrs and followed by IL-4 induction measured after 30 mins by immunoblotting | Mus musculus | 2 | ALA3600288 | single protein format | Scientific Literature | |
3. | ALA922111 | Binding | Reduction of LPS-induced JAK3 phosphorylation in mouse RAW 264.7 cells at 100 ug/mL by Western blot analysis | Mus musculus | 1 | ALA1143984 | cell-based format | Scientific Literature | |
4. | ALA1657306 | Binding | Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assay | Mus musculus | 2 | ALA1649080 | cell-based format | Scientific Literature | |
5. | ALA3117010 | Binding | Inhibition of Jak3 in mouse BA/F3 cells expressing TEL-Jak3 assessed as inhibition of STAT5 phosphorylation by Western blotting analysis | Mus musculus | 1 | ALA3112447 | cell-based format | Scientific Literature | |
6. | ALA3299324 | Binding | Inhibition of JAK3 in mouse HT-2 clone A5E cells assessed as inhibition of interleukin-2-induced STAT-5 phosphorylation at Y694 preincubated for 1 hr followed by interleukin-2 induction measured after 15 mins by FACS analysis | Mus musculus | 1 | ALA3297690 | cell-based format | Scientific Literature | |
7. | ALA3868068 | Binding | Inhibition of JAK3 in mouse HT2 cells assessed as suppression of cell growth | Mus musculus | 6 | ALA3867460 | cell-based format | Scientific Literature | |
8. | ALA4685307 | Binding | Inhibition of JAK3 in mouse T cells assessed as reduction in IL2-stimulated cell proliferation measured after 72 hrs by MTS assay | Mus musculus | 4 | ALA4680201 | cell-based format | Scientific Literature | |
9. | ALA4685308 | Binding | Inhibition of JAK3 in mouse T cells assessed as reduction in anti-CD3/-CD28-stimulated cell proliferation measured after 72 hrs by MTS assay | Mus musculus | 4 | ALA4680201 | cell-based format | Scientific Literature | |
10. | ALA4685319 | Binding | Inhibition of JAK3 in anti-CD3/-CD28 coated mouse T cells assessed as reduction in IL2-induced STAT5 phosphorylation at 10 uM preincubated for 1 hr followed by IL2 stimulation and measured after 30 mins by Western blot analysis | Mus musculus | 3 | ALA4680201 | tissue-based format | Scientific Literature | |
11. | ALA4685320 | Binding | Inhibition of JAK3 in anti-CD3/-CD28 coated mouse T cells assessed as reduction in IL15-induced STAT5 phosphorylation at 10 uM preincubated for 1 hr followed by IL2 stimulation and measured after 30 mins by Western blot analysis | Mus musculus | 3 | ALA4680201 | tissue-based format | Scientific Literature | |
12. | ALA4685321 | Binding | Inhibition of JAK3 in anti-CD3/-CD28 coated mouse T cells assessed as reduction in IL2-induced STAT5 phosphorylation preincubated for 1 hr followed by IL2 stimulation and measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4680201 | tissue-based format | Scientific Literature | |
13. | ALA4685322 | Binding | Inhibition of JAK3 in anti-CD3/-CD28 coated mouse T cells assessed as reduction in IL15-induced STAT5 phosphorylation preincubated for 1 hr followed by IL2 stimulation and measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4680201 | tissue-based format | Scientific Literature | |
14. | ALA4731486 | ADME | Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability by MTT assay | Mus musculus | 3 | ALA4725469 | cell-based format | Scientific Literature | |
15. | ALA4731487 | ADME | Inhibition of JAK3 in mouse BaF3 cells assessed as reduction in cell viability in presence of 0.1 mM H2O2 by MTT assay | Mus musculus | 2 | ALA4725469 | cell-based format | Scientific Literature | |
16. | ALA4731491 | Binding | Inhibition of JAK3 in mouse BaF3/TEL-JAK3 cells assessed as effect on STAT3 phosphorylation at 0.125 to 2 uM by Western blot analysis | Mus musculus | 2 | ALA4725469 | cell-based format | Scientific Literature | |
17. | ALA4731492 | Binding | Inhibition of JAK3 in mouse BaF3/TEL-JAK3 cells assessed as effect on STAT5 phosphorylation at 0.125 to 2 uM by Western blot analysis | Mus musculus | 2 | ALA4725469 | cell-based format | Scientific Literature |