# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA758901 | Functional | Effective agonist concentration to human orexin receptor type 1 determined using the Xlfit program | 79 | ALA1148480 | assay format | Scientific Literature | ||
2. | ALA758902 | Binding | Inhibitory concentration against human orexin-1 receptor (hOX1R) | 29 | ALA1136503 | single protein format | Scientific Literature | ||
3. | ALA757344 | Binding | Binding affinity towards orexin receptor type 1. | 32 | ALA1134731 | single protein format | Scientific Literature | ||
4. | ALA757345 | Binding | Binding affinity to Orexin receptor type 1 was determined using laser scanning cytometry | 3 | ALA1134228 | single protein format | Scientific Literature | ||
5. | ALA757346 | Functional | Compound was tested for antagonist activity expressed as percentage response at 10 uM, relative to maximal orexin-A induced response against OX1 receptor; IA is Inactive | 1 | ALA1134228 | assay format | Scientific Literature | ||
6. | ALA1006172 | Functional | Inhibition of human OX1 receptor expressed in CHO cells assessed as intercellular calcium mobilization by FLIPR assay | Homo sapiens | 37 | ALA1143438 | cell-based format | Scientific Literature | |
7. | ALA973407 | Binding | Binding affinity to OX1 receptor | 6 | ALA1136898 | single protein format | Scientific Literature | ||
8. | ALA1007892 | Functional | Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of receptor-mediated calcium response by FLIPR | Homo sapiens | 22 | ALA1140924 | cell-based format | Scientific Literature | |
9. | ALA1007895 | Binding | Binding affinity to OX1 receptor | 21 | ALA1140924 | single protein format | Scientific Literature | ||
10. | ALA1007897 | Functional | Antagonist activity at human OX1 receptor | Homo sapiens | 29 | ALA1140924 | assay format | Scientific Literature | |
11. | ALA1007908 | Binding | Inhibition of OX1 receptor | 37 | ALA1140924 | single protein format | Scientific Literature | ||
12. | ALA1007910 | Functional | Antagonist activity at OX1 receptor by FLIPR | 13 | ALA1140924 | assay format | Scientific Literature | ||
13. | ALA840217 | Binding | Binding affinity towards human orexin receptor type 1 was determined using [125I]-Orexin A as radio ligand | Homo sapiens | 30 | ALA1137156 | single protein format | Scientific Literature | |
14. | ALA857324 | Functional | Agonist activity against human orexin 1 receptor; EC50; nM | Homo sapiens | 61 | ALA1145783 | assay format | Scientific Literature | |
15. | ALA932893 | Binding | Displacement of [3H](S)-1-[2-(1-methyl-1H-benzoimidazol-2-ylsulfanyl)-acetyl]-pyrrolidine-2-carboxylic acid biphenyl-2-ylamide from human OX1R expressed in CHO cells | Homo sapiens | 20 | ALA1143219 | cell-based format | Scientific Literature | |
16. | ALA932894 | Functional | Antagonist activity at human OX1R expressed in CHOK1 cells assessed as effect on calcium mobilization | Homo sapiens | 18 | ALA1143219 | cell-based format | Scientific Literature | |
17. | ALA1099400 | Functional | Antagonist activity at human OX1 receptor expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assay | Homo sapiens | 15 | ALA1154972 | cell-based format | Scientific Literature | |
18. | ALA1109765 | Binding | Binding affinity to OX1 receptor by radioligand displacement assay | 7 | ALA1156317 | single protein format | Scientific Literature | ||
19. | ALA1109767 | Functional | Antagonist activity at OX1 receptor assessed as inhibition of calcium flux by FLIPR assay | 6 | ALA1156317 | assay format | Scientific Literature | ||
20. | ALA1119822 | Binding | Displacement of [3H](S)-N-(biphenyl-2-yl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX1R expressed in CHO cells after 3 hrs by scintillation counting | Homo sapiens | 9 | ALA1155457 | cell-based format | Scientific Literature |