| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1119374 | B | Activity at LAT1 by Michaelis-Menten constant | 1 | ALA1155529 | single protein format | Scientific Literature | ||
| 2. | ALA3811916 | B | Substrate activity at human LAT1 expressed in HEK cells assessed as efflux rate of [3H]-gabapentin at 200 uM after 5 to 180 secs by scintillation counting based trans-stimulation assay | Homo sapiens | 27 | ALA3808321 | cell-based format | Scientific Literature | |
| 3. | ALA3811917 | B | Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin at 200 uM after 3 mins by scintillation counting based cis-inhibition assay | Homo sapiens | 27 | ALA3808321 | cell-based format | Scientific Literature | |
| 4. | ALA3811918 | B | Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-inhibition assay | Homo sapiens | 3 | ALA3808321 | cell-based format | Scientific Literature | |
| 5. | ALA4234829 | B | Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH | Homo sapiens | 44 | ALA4229477 | cell-based format | Scientific Literature | |
| 6. | ALA4234830 | B | Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake at 200 uM preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH | Homo sapiens | 59 | ALA4229477 | cell-based format | Scientific Literature | |
| 7. | ALA4234831 | B | Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis relative to L-phenylalanine | Homo sapiens | 63 | ALA4229477 | cell-based format | Scientific Literature | |
| 8. | ALA4234832 | B | Binding affinity to LAT1 (unknown origin) by in-vitro cell uptake assay | Homo sapiens | 1 | ALA4229477 | single protein format | Scientific Literature | |
| 9. | ALA4234833 | B | Substrate activity at recombinant human LAT1 expressed in Xenopus laevis oocytes assessed as Km by measuring L-[14C]-leucine uptake by Eadie-Hofstee plot method | Homo sapiens | 2 | ALA4229477 | cell-based format | Scientific Literature | |
| 10. | ALA4235004 | B | Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting method | Homo sapiens | 3 | ALA4229488 | cell-based format | Scientific Literature | |
| 11. | ALA4235005 | A | Drug uptake in human MCF7 cells assessed as LAT1-mediated drug transportation rate at 3.125 to 100 uM after 10 mins by LC-MS analysis | Homo sapiens | 1 | ALA4229488 | cell-based format | Scientific Literature | |
| 12. | ALA4235006 | A | Drug uptake in human MCF7 cells assessed as LAT1-mediated drug transportation rate at 25 to 50 uM after 10 mins by LC-MS analysis | Homo sapiens | 2 | ALA4229488 | cell-based format | Scientific Literature | |
| 13. | ALA4386799 | B | Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis relative to L-phenylalanine | Homo sapiens | 16 | ALA4385624 | cell-based format | Scientific Literature | |
| 14. | ALA4386800 | B | Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH | Homo sapiens | 17 | ALA4385624 | cell-based format | Scientific Literature | |
| 15. | ALA4386801 | B | Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis | Homo sapiens | 16 | ALA4385624 | cell-based format | Scientific Literature | |
| 16. | ALA4386802 | B | Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis | Homo sapiens | 1 | ALA4385624 | cell-based format | Scientific Literature | |
| 17. | ALA4407759 | B | Inhibition of recombinant human LAT1 | Homo sapiens | 1 | ALA4406816 | single protein format | Scientific Literature | |
| 18. | ALA4425978 | B | Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation counting | Homo sapiens | 1 | ALA4425108 | cell-based format | Scientific Literature | |
| 19. | ALA4425979 | B | Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation counting | Homo sapiens | 1 | ALA4425108 | cell-based format | Scientific Literature | |
| 20. | ALA4425981 | B | Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 2 | ALA4425108 | cell-based format | Scientific Literature |
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