# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA837694 | F | Inhibition of PrPC polymerization by PrP-res at 100 uM | Mus musculus | 50 | assay format | Scientific Literature | ||
2. | ALA826508 | F | Inhibition of PrP-res formation in SMB (Scrapie mouse brain) cells at 10 uM | Mus musculus | 53 | tissue-based format | Scientific Literature | ||
3. | ALA864039 | B | Binding affinity to mouse PrPC at 40 uM | Mus musculus | 32 | single protein format | Scientific Literature | ||
4. | ALA918558 | B | Binding affinity at mouse PrPC at 40 uM by SPR assay | Mus musculus | 30 | single protein format | Scientific Literature | ||
5. | ALA963564 | B | Inhibition of manganese-induced aggregation in mouse recombinant PrP assessed as PrP-res formation at 100 uM after 30 mins relative to control | Mus musculus | 55 | single protein format | Scientific Literature | ||
6. | ALA963565 | B | Inhibition of mouse recombinant PrP interaction with scrapie mouse brain PrP-res assessed as PrP-res formation at 100 uM after 30 mins by aggregation assay relative to control | Mus musculus | 10 | assay format | Scientific Literature | ||
7. | ALA975927 | B | Binding affinity to mouse prion protein by surface plasmon resonance assay | Mus musculus | 26 | single protein format | Scientific Literature | ||
8. | ALA1039057 | B | Binding affinity to mouse PrP up to 40 uM by surface plasmon resonance assay | Mus musculus | 6 | single protein format | Scientific Literature | ||
9. | ALA1635193 | B | Antiprion activity against mouse recombinant PrP expressed in Fukuoka-1 stain infected mouse GT1-7 cells assessed as remaining PrP-res level at 10 uM after 72 hrs by Western blotting relative to control | Mus musculus | 27 | cell-based format | Scientific Literature | ||
10. | ALA1635194 | B | Antiprion activity against mouse recombinant PrP expressed in Fukuoka-1 stain infected mouse GT1-7 cells at 10 uM after 72 hrs by Western blotting | Mus musculus | 4 | cell-based format | Scientific Literature | ||
11. | ALA1635195 | B | Binding affinity to mouse recombinant PrP (121-231) after 10 mins by surface plasmon resonance assay | Mus musculus | 14 | single protein format | Scientific Literature | ||
12. | ALA2328048 | B | Inhibition of mouse PrP (23-230) fibril formation assessed as extension of lag phase at 50 uM by amyloid seeding assay (Rvb = 50 hrs) | Mus musculus | 3 | single protein format | Scientific Literature | ||
13. | ALA4028450 | B | Activity at mouse prion protein expressed in Escherichia coli | Mus musculus | 1 | assay format | Scientific Literature | ||
14. | ALA5149189 | B | Inhibition of full length mouse recombinant MoPrP (23 to 231 residues) aggregation in RML prion infected mouse ScN2a cell lysate using PrPSc as substrate by Thioflavin T based fluorometric assay | Mus musculus | 1 | subcellular format | Scientific Literature | ||
15. | ALA5149191 | B | Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation at 2 to 10 uM in presence of 1 to 0.2 uM quinacrine by Western blotting analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
16. | ALA5149192 | B | Synergistic anti-prion activity of mouse ScN2a cells infected with RML prion assessed as reduction of RML accumulation by isobologram analysis | Mus musculus | 2 | cell-based format | Scientific Literature |