# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA871407 | B | Inhibition of PACAP receptor at 1 uM | Homo sapiens | 1 | ALA1138064 | single protein format | Scientific Literature | |
2. | ALA911629 | F | Activity at human VPAC2 receptor in CHO cells by measuring cAMP accumulation | Homo sapiens | 2 | ALA1138207 | cell-based format | Scientific Literature | |
3. | ALA911644 | B | Displacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cells | Homo sapiens | 2 | ALA1138207 | cell-based format | Scientific Literature | |
4. | ALA2160805 | F | Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter | Homo sapiens | 4 | ALA2157898 | cell-based format | Scientific Literature | |
5. | ALA3106155 | F | Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay | Homo sapiens | 16 | ALA3102798 | cell-based format | Scientific Literature | |
6. | ALA3738746 | B | Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis | Homo sapiens | 4 | ALA3734733 | cell-based format | Scientific Literature | |
7. | ALA3738750 | F | Activation of VPAC2 in human SH-SY5Y cells assessed as stimulation of forskolin-induced cAMP production at 10'-7 to 10'-5 M after 30 mins | Homo sapiens | 3 | ALA3734733 | cell-based format | Scientific Literature | |
8. | ALA3880367 | F | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged VIPR2 expressed in HEK293 cells co-expressing CAMYEL assessed as inhibition of VIP-induced cAMP accumulation at 0.5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 101 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
9. | ALA3880368 | F | Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced cAMP accumulation incubated for 30 mins by HTRF assay | Homo sapiens | 1 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
10. | ALA3880369 | F | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged VIPR2 expressed in CHO cells co-expressing CAMYEL assessed as inhibition of VIP-induced cAMP accumulation preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay | Homo sapiens | 1 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
11. | ALA3880370 | B | Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced beta-arrestin 2 binding incubated for 2 hrs by beta-galactosidase assay | Homo sapiens | 1 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
12. | ALA3880371 | F | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged VIPR2 expressed in HEK293 cells co-expressing CAMYEL assessed as inhibition of VIP-induced cAMP accumulation at 5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 101 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
13. | ALA3880372 | F | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged VIPR2 expressed in HEK293 cells co-expressing CAMYEL assessed as inhibition of VIP-induced cAMP accumulation at 1 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 101 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
14. | ALA3880373 | B | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding at 5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 101 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
15. | ALA3880374 | B | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding at 1 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 101 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
16. | ALA3880375 | B | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding at 0.5 uM preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay relative to control | Homo sapiens | 104 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
17. | ALA3880376 | B | Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay | Homo sapiens | 57 | ALA3879914 | cell-based format | Patent Bioactivity Data | |
18. | ALA4257230 | F | Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay | Homo sapiens | 33 | ALA4257221 | cell-based format | Patent Bioactivity Data | |
19. | ALA4312673 | B | Activity at human VPAC2 at 10 uM | Homo sapiens | 1 | ALA4311943 | single protein format | Scientific Literature | |
20. | ALA4883617 | B | PRESTO-Tango GPCRome screening (VIPR2) | 1 | ALA4507309 | single protein format | Donated Chemical Probes - SGC Frankfurt |