# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3592311 | Binding | Allosteric antagonist activity against FPR2 (unknown origin) | Homo sapiens | 1 | ALA3588798 | single protein format | Scientific Literature | |
2. | ALA3592312 | Functional | Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay | Homo sapiens | 21 | ALA3588798 | cell-based format | Scientific Literature | |
3. | ALA3592313 | Functional | Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay | Homo sapiens | 2 | ALA3588798 | cell-based format | Scientific Literature | |
4. | ALA3592314 | Functional | Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay | Homo sapiens | 3 | ALA3588798 | cell-based format | Scientific Literature | |
5. | ALA3592315 | Functional | Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay | Homo sapiens | 1 | ALA3588798 | cell-based format | Scientific Literature | |
6. | ALA3592316 | Functional | Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay | Homo sapiens | 1 | ALA3588798 | cell-based format | Scientific Literature | |
7. | ALA3592680 | Functional | Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay | Homo sapiens | 12 | ALA3588779 | cell-based format | Scientific Literature | |
8. | ALA3592682 | Functional | Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to WKYMVm | Homo sapiens | 8 | ALA3588779 | cell-based format | Scientific Literature | |
9. | ALA3592683 | Functional | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid | Homo sapiens | 12 | ALA3588779 | single protein format | Scientific Literature | |
10. | ALA3592684 | Functional | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid | Homo sapiens | 12 | ALA3588779 | single protein format | Scientific Literature | |
11. | ALA3592685 | Functional | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF in absence of probenecid | Homo sapiens | 6 | ALA3588779 | single protein format | Scientific Literature | |
12. | ALA3592686 | Functional | Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay relative to fMLF in presence of probenecid | Homo sapiens | 8 | ALA3588779 | single protein format | Scientific Literature | |
13. | ALA3734552 | Functional | Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 413 | ALA3727351 | cell-based format | Patent Bioactivity Data | |
14. | ALA867962 | Functional | Activity at human FPRL1-mediated calcium mobilization in CHO cells | Homo sapiens | 36 | ALA1138936 | cell-based format | Scientific Literature | |
15. | ALA925628 | Functional | Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay | Homo sapiens | 17 | ALA1140550 | cell-based format | Scientific Literature | |
16. | ALA1772746 | Functional | Antagonist activity at FPR2 in human neutrophils assessed as inhibition of SHHGtide-stimulated intracellular calcium mobilisation at 50 uM by FLIPR assay | Homo sapiens | 2 | ALA1770079 | cell-based format | Scientific Literature | |
17. | ALA4352680 | Functional | Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay | Homo sapiens | 47 | ALA4350966 | cell-based format | Scientific Literature | |
18. | ALA4352681 | Binding | Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay | Homo sapiens | 47 | ALA4350966 | cell-based format | Scientific Literature | |
19. | ALA3411151 | Binding | Binding affinity to human FPR2 receptor | Homo sapiens | 1 | ALA3407365 | single protein format | Scientific Literature | |
20. | ALA3411158 | Binding | Binding affinity to human FPR2 receptor expressed in HEK cells assessed as heat release at 155 nmol by isothermal titration calorimetry | Homo sapiens | 1 | ALA3407365 | cell-based format | Scientific Literature |