| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA863268 | B | Inhibition of human CCR6 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA923001 | B | Binding affinity to CCR6 receptor | 1 | single protein format | Scientific Literature | |||
| 3. | ALA928586 | B | Inhibition of CCR6 upto 1 uM | 1 | single protein format | Scientific Literature | |||
| 4. | ALA1010852 | B | Inhibition of CCR6 receptor | 1 | single protein format | Scientific Literature | |||
| 5. | ALA1114084 | B | Binding affinity to human CCR6 receptor | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA1738164 | F | PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] | Homo sapiens | 283 | assay format | PubChem BioAssays | ||
| 7. | ALA1794474 | F | PUBCHEM_BIOASSAY: SAR analysis of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159, AID540340] | 19 | assay format | PubChem BioAssays | |||
| 8. | ALA2175765 | F | Inhibition of CCR6 expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA2328031 | B | Antagonist activity at CCR6 (unknown origin) assessed as inhibition of chemotaxis at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA2328623 | F | Antagonist activity at CCR6 (unknown origin) assessed as inhibition of calcium flux at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA2328644 | B | Binding affinity to CCR6 (unknown origin) at 10 uM by radioligand displacement assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA2351069 | B | Antagonist activity at CCR6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3097213 | B | Inhibition of CCR6 (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3215253 | F | PubChem BioAssay. SAR analysis of small molecule antagonists of the CXCR6 receptor using a CCR6 receptor luminescent beta-arrestin counterscreen. (Class of assay: confirmatory) | 8 | assay format | PubChem BioAssays | |||
| 15. | ALA3707809 | F | FLIPR Assay: The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were added to the cells expressing the chemokine receptor of interest and the agonist activity was read at 10 seconds. After a further incubation for 10 minutes, the cells were activated, with a concentration equivalent to the AC80, using a reference agonist in order to detect whether this compound exhibits antagonist activity.Each cell line expressing a chemokine receptor was established on the basis of the Chem-1 cell stably expressing the recombinant form of the chemokine receptor and also an associated G protein, with the aim of coupling the receptor to the calcium signalling pathway. 21 receptors belonging to the chemokine receptor family (CCRs and CXCRs) were analyzed. All the CXCR2 antagonists were tested in a dose-dependent manner and the concentration corresponding to 50% inhibition of the response was determined (IC.sub.50). | 4 | cell-based format | BindingDB Database | |||
| 16. | ALA3863315 | F | Antagonist activity at human CCR6 assessed as inhibition of CCL20/MIP-3alpha-induced calcium flux | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA3863322 | F | Agonist activity at human CCR6 assessed as induction of calcium flux | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 18. | ALA4028339 | F | Antagonist activity at human CCR6 expressed in CHOK1 cells assessed as inhibition of CCL20-induced cAMP accumulation at 10 uM preincubated for 30 mins followed agonist addition measured after 30 to 60 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4037564 | B | Agonist activity at CCR6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4037582 | B | Antagonist activity at CCR6 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature |
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