| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA854334 | F | Antagonistic potency at human TLR4 expressed in HEK293 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA867199 | F | Inhibition of induction of NF-kappaB by LPS in HEK293 cells co-transfected with TLR4, CD14 and MD2 | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA1827811 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-8 release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 4. | ALA1827812 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 5. | ALA1827813 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA1827814 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA1827815 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-8 release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA1827816 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of TNFalpha release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA1827817 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release at 500 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA1827818 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as inhibition of IL-6 release at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA1827819 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma IL-8 level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA1827820 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma TNFalpha level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA1827821 | B | Inhibition of LPS-induced TLR4 activation in human whole blood assessed as reduction in plasma IL-6 level at 250 uM preincubated for 5 to 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA2038974 | F | Agonist activity at TLR4 expressed in human 293T cells assessed as LPS-mediated NF-kappaB activation after 6 hrs by dual luciferase reporter gene assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA939463 | F | Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production pre-incubated for 30 mins before LPS challenge measured after 18 hrs by ELISA | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 16. | ALA939464 | F | Agonist activity at TLR4 in human PBMC assessed as induction of TNFalpha production after 18 hrs by sandwich ELISA | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 17. | ALA990601 | F | Antagonist activity at human TLR4 expressed in HE293 cells by ELAM1-luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA990602 | F | Antagonist activity at TLR4 in human PBMC cells assessed as suppression of LPS-induced cytokine upregulation | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA990604 | B | Inhibition of human TLR4-mediated cytokine production in mouse macrophages | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 20. | ALA990605 | F | Antagonist activity at TLR4 in human HL60 cells assessed as inhibition of LPS-induced cytokine production | Homo sapiens | 1 | cell-based format | Scientific Literature |
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