| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA860291 | F | Antagonistic potency at TLR2 expressed in HEK293 cells | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 2. | ALA853288 | F | Antagonistic activity at TLR in human PBMC | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA867221 | F | Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells at 25 uM | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA867222 | F | Inhibition of TLR2 agonist Pam3Cys-Ser-(Lys)4-OH-mediated IL8 secretion in THP1 cells | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 5. | ALA867224 | F | Inhibition of TLR2-mediated IL-8 secretion in THP-1 cells | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 6. | ALA2049616 | F | Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation after 12 hrs by secretory alkaline phosphatase reporter gene assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 7. | ALA2049618 | F | Agonist activity at human TLR2 expressed in HEK293 cells assessed as NFkappaB translocation at 10 uM after 12 hrs by secretory alkaline phosphatase reporter gene assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 8. | ALA2049619 | F | Antagonistic activity at human TLR2 expressed in HEK293 cells assessed as inhibition of PAM2CS-induced NFkappaB translocation by secretory alkaline phosphatase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA2049621 | F | Antagonistic activity at human TLR2 expressed in HEK293 cells assessed as inhibition of lipoteichoic acid-induced NFkappaB translocation by secretory alkaline phosphatase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 10. | ALA1839616 | F | Agonist activity at TLR2 expressed in HEK293 cells co-expressing pNF-kappaB-Luc Cis assessed as NF-kappaB activation at 100 nM by luciferase reporter gene assay | 2 | cell-based format | Scientific Literature | |||
| 11. | ALA1926410 | F | Agonist activity at human TLR2 expressed in HEK293 cells assessed as NF-kappaB induction measured soluble alkaline phosphatase after 12 hrs by spectrophotometric analysis | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 12. | ALA2013302 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity after 19 hrs by quanti-blue colorimetric assay relative to 0.1 uM of Pam2CAG | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA2013303 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity after 19 hrs by quanti-blue colorimetric assay relative to 10 uM of Pam3CAG | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA2013304 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity treated with PC/PG/Chol liposomes formulation at 0.1 uM after 19 hrs by quanti-blue colorimetric assay in presence of anti-mTLR2 antibody | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA2013305 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity treated with PC/PG/Chol liposomes formulation after 19 hrs by quanti-blue colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA2013306 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity treated with PBS containing 2% DMSO formulation after 19 hrs by quanti-blue colorimetric assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 17. | ALA2013307 | F | Agonist activity at TLR2 in human THP1-Blue-CD14 cells transfected with pSEAP-NF-kappaB assessed as secreted embryonic alkaline phosphatase activity treated with PC/PG/Chol liposomes formulation at 10 uM after 19 hrs by quanti-blue colorimetric assay in presence of anti-mTLR2 antibody | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA2013308 | F | Agonist activity at TLR2 in human HEK-Blue-2 cells | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 19. | ALA989789 | F | Antagonist activity at human TLR2 expressed in HE293 cells co-transfected with pELAM by luciferase reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA990600 | B | Inhibition of TLR2-mediated IL8 secretion in human THP1 cells | Homo sapiens | 1 | cell-based format | Scientific Literature |
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