| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA869679 | B | Inhibition of human recombinant CYP2J2 expressed in baculovirus-infected Sf9 insect cells | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 2. | ALA1058985 | A | Inhibition of CYP2J2 | 3 | single protein format | Scientific Literature | |||
| 3. | ALA1074710 | A | Inhibition of CYP2J2 | 3 | single protein format | Scientific Literature | |||
| 4. | ALA1119168 | B | Inhibition of CYP2J2 | 7 | single protein format | Scientific Literature | |||
| 5. | ALA2072825 | A | Inhibition of CYP2J2 | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 6. | ALA3371006 | A | Inhibition of human CYP2J2 assessed as remaining activity at 10 uM | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 7. | ALA3509247 | A | Enzyme kinetics constant (Km value) for CYP2J2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 8. | ALA3509256 | A | Enzyme kinetics constant (Vmax value) for CYP2J2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 9. | ALA3509265 | A | Metabolic clearance (ul.min.nmol-1 CYP) of aliskiren hemifumarate for CYP2J2 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 10. | ALA3541780 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3537740 | A | Drug metabolism assessed as recombinant CYP2J2 (unknown origin)-mediated 2-(5-chloro-4-(2-(2-chloro-4-cyclopropylphenylsulfonamido)-4-(1-hydroxy-2-methylpropan-2-ylcarbamoyl)phenoxy)-2-fluorophenyl)acetic acid formation at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3537745 | A | Drug metabolism assessed as recombinant CYP2J2 (unknown origin)-mediated compound formation treated with AMG 853 at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA3538082 | A | Drug metabolism assessed as recombinant CYP2J2 (unknown origin)-mediated 2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-(1-hydroxycyclopropyl)phenylsulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetic acid formation at 10 uM after 30 mins by LC-MS/MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3541853 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3536999 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated total GSH conjugate formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis in presence of GSH and hGST P1-1 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA3541894 | A | Drug metabolism assessed as human CYP2J2-mediated compound formation from 5 to 20 uM [14C]boceprevir after 120 mins by LC-MS/FSA method relative to total [14C]boceprevir | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA3539712 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3539723 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3540041 | A | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated total GSH conjugate formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis in presence of GSH and hGST P1-1 | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA3538278 | A | Drug metabolism assessed as recombinant CYP2J2 (unknown origin)-mediated compound formation measured per nmol protein treated with AMG 853 after 15 mins by LC-MS/MS analysis | Homo sapiens | 2 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!