| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA862736 | Binding | Inhibitory activity against CF40.NS3pro from Dengue virus type 2 | dengue virus type 2 | 12 | ALA1147780 | single protein format | Scientific Literature | |
| 2. | ALA863929 | Binding | Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2B | Dengue virus | 30 | ALA1147782 | single protein format | Scientific Literature | |
| 3. | ALA861153 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 40 ppm | dengue virus type 2 | 3 | ALA1148500 | single protein format | Scientific Literature | |
| 4. | ALA861154 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 80 ppm | dengue virus type 2 | 3 | ALA1148500 | single protein format | Scientific Literature | |
| 5. | ALA861155 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 120 ppm | dengue virus type 2 | 5 | ALA1148500 | single protein format | Scientific Literature | |
| 6. | ALA861156 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 160 ppm | dengue virus type 2 | 3 | ALA1148500 | single protein format | Scientific Literature | |
| 7. | ALA861157 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 240 ppm | dengue virus type 2 | 5 | ALA1148500 | single protein format | Scientific Literature | |
| 8. | ALA861158 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Boc-Gly-Arg-Arg-MCA cleavage at 400 ppm | dengue virus type 2 | 5 | ALA1148500 | single protein format | Scientific Literature | |
| 9. | ALA861159 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 120 ppm | dengue virus type 2 | 4 | ALA1148500 | single protein format | Scientific Literature | |
| 10. | ALA861160 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 240 ppm | dengue virus type 2 | 4 | ALA1148500 | single protein format | Scientific Literature | |
| 11. | ALA861161 | Binding | Inhibition of dengue2 virus NS2B/NS3 protease activity for Ac-Thr-Arg-Arg-MCA cleavage at 400 ppm | dengue virus type 2 | 4 | ALA1148500 | single protein format | Scientific Literature | |
| 12. | ALA861162 | Binding | Inhibition of dengue2 virus NS3 protease | dengue virus type 2 | 5 | ALA1148500 | single protein format | Scientific Literature | |
| 13. | ALA1794550 | Functional | PUBCHEM_BIOASSAY: Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588708, AID588742] | 1,013 | ALA1201862 | assay format | PubChem BioAssays | ||
| 14. | ALA4353043 | Binding | Inhibition of dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli at 50 uM using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with enzyme for 15 mins followed by substrate addition measured for every 1 sec for 15 mins by fluorescence plate reader based HPLC analysis relative to control | dengue virus type 2 | 13 | ALA4350980 | assay format | Scientific Literature | |
| 15. | ALA4353047 | Binding | Inhibition of dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with enzyme for 15 mins followed by substrate addition measured for every 1 sec for 15 mins by fluorescence plate reader based HPLC analysis | dengue virus type 2 | 1 | ALA4350980 | assay format | Scientific Literature | |
| 16. | ALA4353050 | Binding | Time-dependent inhibition of dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli at 50 uM using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with enzyme for 20 to 40 mins followed by substrate addition measured for every 1 sec for 15 mins by fluorescence plate reader based HPLC analysis | dengue virus type 2 | 4 | ALA4350980 | assay format | Scientific Literature | |
| 17. | ALA4353051 | Binding | Inhibition of dengue virus serotype 2 His-tagged NS2B catalytic domain-NS3 protease expressed in Escherichia coli at 100 uM using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with enzyme for 1 hr followed by substrate addition measured for every 1 sec for 15 mins by fluorescence plate reader based HPLC analysis relative to control | dengue virus type 2 | 1 | ALA4350980 | assay format | Scientific Literature | |
| 18. | ALA4353052 | Binding | Reversible covalent binding affinity at dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli assessed as acyl-enzyme adduct formation at 100 uM incubated for 5 to 30 mins by ESI-MS analysis | dengue virus type 2 | 1 | ALA4350980 | assay format | Scientific Literature | |
| 19. | ALA4353053 | Binding | Reversible covalent binding affinity at dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli assessed as acyl-enzyme adduct formation at 100 uM incubated for 20 hrs by ESI-MS analysis | dengue virus type 3 | 1 | ALA4350980 | assay format | Scientific Literature | |
| 20. | ALA4353060 | Binding | Inhibition of dengue virus serotype 2 His-tagged NS2B cofactor domain-NS3 protease expressed in Escherichia coli at 1 mM using 2-Abz-Nle-Lys-Arg-Arg-Ser-(3-NO2)-Tyr-NH2 as substrate preincubated with enzyme for 15 mins followed by substrate addition measured for every 1 sec for 15 mins by fluorescence plate reader based HPLC analysis relative to control | dengue virus type 2 | 9 | ALA4350980 | assay format | Scientific Literature |
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