# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA868711 | Functional | Effect of compound on antigen presentation in mouse A20 cells transfected with PC-specific mIgM by IL-2 secretion | 7 | ALA1141213 | cell-based format | Scientific Literature | ||
2. | ALA1250078 | Functional | Induction of apoptosis in mouse CD40-expressing mouse A20 cells assessed as decrease in mitochondrial membrane potential after 16 hrs by mean fluorescence intensity | Mus musculus | 1 | ALA1240299 | cell-based format | Scientific Literature | |
3. | ALA3096511 | Functional | Inhibition of ovalbumin-induced antigen presentation in mouse A20 cells treated 1 hr before ovalbumin addition incubated for 16 hrs followed by co-cultured with DO10.10 T-cell hybridoma cells for 24 hrs assessed as IL-2 production by luminex single-bead analysis | Mus musculus | 30 | ALA3091448 | cell-based format | Scientific Literature | |
4. | ALA4042772 | Functional | Cytotoxicity against mouse A20 cells assessed as reduction in cell viability after 4 hrs by MTT assay | Mus musculus | 18 | ALA4041537 | cell-based format | Scientific Literature | |
5. | ALA4042775 | Functional | Cytotoxicity against mouse A20 cells assessed as reduction in cell viability after 4 hrs in presence of CPP by MTT assay | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
6. | ALA4042776 | Functional | Cytotoxicity against mouse A20 cells assessed as reduction in cell viability after 4 hrs in presence of AMP by MTT assay | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
7. | ALA4042795 | Functional | Induction of mitochondrial membrane potential disruption in mouse A20 cells at cytotoxic IC50 after 4 hrs by TMRE dye based flow cytometry | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
8. | ALA4042803 | Functional | Induction of necrosis in mouse A20 cells assessed as cell membrane disruption at cytotoxic IC50 after 1 hr by Annexin-V FITC/propidium iodide staining based flow cytometry relative to control | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
9. | ALA4042804 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-2 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
10. | ALA4042805 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-3/7 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
11. | ALA4042806 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-6 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
12. | ALA4042807 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-8 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
13. | ALA4042808 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-9 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
14. | ALA4042809 | Functional | Induction of apoptosis in mouse A20 cells assessed as caspase-10 activation at cytotoxic IC50 preincubated for 1 hr followed by 7-amino-4-trifluoro methylcoumarin-labeled substrate addition measured after 2 hrs by fluorescence assay | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
15. | ALA4042814 | Functional | Cytotoxicity against mouse A20 cells assessed as extrusion of intracellular material at cytotoxic IC50 after 90 mins by scanning electron microscopic method | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
16. | ALA4042815 | Functional | Cytotoxicity against mouse A20 cells assessed as extrusion of intracellular material at 2.5 times cytotoxic IC50 after 45 mins by scanning electron microscopic method | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
17. | ALA4042816 | Functional | Cytotoxicity against mouse A20 cells assessed as extrusion of intracellular material at 10 times cytotoxic IC50 after 15 mins by scanning electron microscopic method | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
18. | ALA4042817 | Functional | Antitumor activity against mouse A20 cells implanted in Balb/c mouse assessed as mean survival time at 25 mg/ml, qd intralesionally administered for 3 consecutive days (Rvb = 22 day) | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature | |
19. | ALA4042818 | Functional | Antitumor activity against mouse A20 cells implanted in Balb/c mouse assessed as overall survival of mouse at 25 mg/ml, qd intralesionally administered for 3 consecutive days measured after 55 days relative to control | Mus musculus | 2 | ALA4041537 | cell-based format | Scientific Literature | |
20. | ALA4042819 | Functional | Antitumor activity against mouse A20 cells implanted in Balb/c mouse assessed as tumor growth inhibition at 25 mg/ml, qd intralesionally administered for 3 consecutive days followed by rechallenging of cured mouse with A20 cells 4 weeks post dose measured up to 10 days | Mus musculus | 1 | ALA4041537 | cell-based format | Scientific Literature |