| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3825050 | B | Non-competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes with increasing [14C]-SAM levels and fixed AFC substrate level by Lineweaver-Burk plot analysis | Homo sapiens | 1 | ALA3822411 | cell membrane format | Scientific Literature | |
| 2. | ALA3825051 | B | Competitive inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes using increasing AFC substrate levels and fixed [14C]-SAM level by Lineweaver-Burk plot analysis | Homo sapiens | 1 | ALA3822411 | cell membrane format | Scientific Literature | |
| 3. | ALA3825052 | B | Inhibition of human isoprenylcysteine carboxyl methyltransferase expressed in yeast His10myc3N-Icmt membranes using AFC substrate and [14C]-SAM and incubated for 30 mins by liquid scintillation counting based methyltransferase vapor diffusion assay | Homo sapiens | 13 | ALA3822411 | cell membrane format | Scientific Literature | |
| 4. | ALA864902 | B | Inhibition of human Icmt in Saccharomyces cerevisiae cell membrane relative to control by SPA | Homo sapiens | 6 | ALA1145318 | assay format | Scientific Literature | |
| 5. | ALA864903 | B | Inhibition of human Icmt by methanol vapour diffusion assay | Homo sapiens | 6 | ALA1145318 | single protein format | Scientific Literature | |
| 6. | ALA901855 | B | Displacement of [3H]SAM from Icmt relative to SAH | Homo sapiens | 1 | ALA1138281 | single protein format | Scientific Literature | |
| 7. | ALA901856 | B | Displacement of [3H]biotin from Icmt upto 100 uM by Artifact assay relative to tartrazine | Homo sapiens | 1 | ALA1138281 | single protein format | Scientific Literature | |
| 8. | ALA885678 | B | Inhibition of ICMT expressed in Sf9 cells | Homo sapiens | 70 | ALA1139053 | cell-based format | Scientific Literature | |
| 9. | ALA1259548 | B | Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting | 46 | ALA1255568 | cell-based format | Scientific Literature | ||
| 10. | ALA1772078 | B | Inhibition of human ICMT at 10 uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | Homo sapiens | 39 | ALA1770082 | single protein format | Scientific Literature | |
| 11. | ALA1772079 | B | Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | Homo sapiens | 6 | ALA1770082 | single protein format | Scientific Literature | |
| 12. | ALA1772080 | B | Inhibition of human ICMT at 10uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | Homo sapiens | 1 | ALA1770082 | single protein format | Scientific Literature | |
| 13. | ALA1803543 | B | Inhibition of ICMT in human HCT116 cells assessed as accumulation of ras in cytosolic fraction at up to 25 uM after 18 hrs by Western blot analysis | Homo sapiens | 2 | ALA1800067 | cell-based format | Scientific Literature | |
| 14. | ALA1803544 | B | Inhibition of recombinant ICMT expressed in Sf9 cells using [3H]-AdoMet after 20 mins by scintillation counter | 1 | ALA1800067 | cell-based format | Scientific Literature | ||
| 15. | ALA1803545 | B | Competitive inhibition of human recombinant C-terminal His6-tagged ICMT using 1 to 10 times Km of N-acetyl-S-geranylgeranylcysteine as substrate | Homo sapiens | 1 | ALA1800067 | single protein format | Scientific Literature | |
| 16. | ALA1803546 | B | Activity at human recombinant C-terminal His6-tagged ICMT using prenylated N-acetyl-S-geranylgeranylcysteine as substrate by radiometric assay | Homo sapiens | 1 | ALA1800067 | single protein format | Scientific Literature | |
| 17. | ALA1803547 | B | Uncompetitive inhibition of human recombinant C-terminal His6-tagged ICMT using 1 time Km of S-adenosylmethionine as substrate | Homo sapiens | 1 | ALA1800067 | single protein format | Scientific Literature | |
| 18. | ALA1803548 | B | Uncompetitive inhibition of human recombinant C-terminal His6-tagged ICMT using 10 times Km of S-adenosylmethionine as substrate | Homo sapiens | 1 | ALA1800067 | single protein format | Scientific Literature | |
| 19. | ALA1803626 | B | Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor substrate after 1 hr by fluorometric assay | Homo sapiens | 85 | ALA1800067 | single protein format | Scientific Literature | |
| 20. | ALA1803627 | B | Inhibition of ICMT in human HCT116 cells assessed as accumulation of ras in cytosolic fraction after 18 hrs by Western blot analysis | Homo sapiens | 3 | ALA1800067 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!