# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA917907 | F | Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis | Homo sapiens | 11 | ALA1147137 | cell-based format | Scientific Literature | |
2. | ALA917908 | F | Agonist activity at human P2Y14 expressed in COS7 cells assessed as stimulation of PLC-mediated [3H]inositol hydrolysis at 100 uM | Homo sapiens | 19 | ALA1147137 | cell-based format | Scientific Literature | |
3. | ALA902452 | F | Agonist activity at human P2Y14 receptor expressed in COS7 cells assessed as stimulation of PLC | Homo sapiens | 4 | ALA1138408 | cell-based format | Scientific Literature | |
4. | ALA974337 | F | Agonist activity at UDP-glucose activated human P2Y14 receptor expressed in human COS7 cells coexpressing phospholipase C-activating G protein Galphaq/I assessed as phosphoinositide hydrolysis at 10 uM by scintillation proximity assay | Homo sapiens | 1 | ALA1136919 | cell-based format | Scientific Literature | |
5. | ALA1045264 | F | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production | Homo sapiens | 28 | ALA1156754 | cell-based format | Scientific Literature | |
6. | ALA1045267 | F | Agonist activity at human P2Y14 receptor expressed in HEK293 cells coexpressing phospholipase C-activating Gi protein cells assessed as inhibition of forskolin induced [3H]cAMP production at 10 uM | Homo sapiens | 2 | ALA1156754 | cell-based format | Scientific Literature | |
7. | ALA1045995 | F | Agonist activity at human P2Y14 receptor expressed in human COS7 cells | Homo sapiens | 23 | ALA1152500 | cell-based format | Scientific Literature | |
8. | ALA1045997 | F | Agonist activity at human P2Y14 receptor expressed in human COS7 cells at 10 uM | Homo sapiens | 6 | ALA1152500 | cell-based format | Scientific Literature | |
9. | ALA1119549 | F | Agonist activity at human recombinant P2Y14 receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation proximity assay | Homo sapiens | 4 | ALA1155485 | cell-based format | Scientific Literature | |
10. | ALA2339544 | B | Inhibition of human P2Y14 receptor | Homo sapiens | 5 | ALA2331383 | single protein format | Scientific Literature | |
11. | ALA3224909 | F | Agonist activity at human P2Y14 receptor expressed in rat C6 cells assessed as inhibition of forskolin-stimulated adenylate cyclase up to 10 uM | Homo sapiens | 1 | ALA3217604 | cell-based format | Scientific Literature | |
12. | ALA3592309 | B | Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta | Homo sapiens | 9 | ALA3588816 | cell-based format | Scientific Literature | |
13. | ALA3592310 | B | Agonist activity at recombinant human P2Y14 receptor expressed in African green monkey COS7 cells co-transfected with Galphaqi assessed as stimulation of phospholipase Cbeta at 10 uM | Homo sapiens | 7 | ALA3588816 | cell-based format | Scientific Literature | |
14. | ALA4189951 | B | Displacement of MRS4174 from human P2Y14R expressed in CHO cells preincubated for 30 mins followed by MRS4174 addition measured after 30 mins by flow cytometric method | Homo sapiens | 44 | ALA4184336 | cell-based format | Scientific Literature | |
15. | ALA4200104 | F | Agonist activity at human P2Y14 receptor transfected in CHO cells assessed as induction of beta-arrestin translocation | Homo sapiens | 5 | ALA4196130 | cell-based format | Scientific Literature | |
16. | ALA4263270 | F | Agonist activity at human P2Y14 receptor expressed in human 1321N1 cells assessed as induction of calcium mobilization at 10 uM measured over 2 mins by Fluo-4 dye-based FLIPR method relative to control | Homo sapiens | 1 | ALA4261568 | cell-based format | Scientific Literature | |
17. | ALA4349438 | B | Inhibition of human P2Y14 receptor expressed in CHO cells by fluorescence assay | Homo sapiens | 1 | ALA4346722 | cell-based format | Scientific Literature | |
18. | ALA4362017 | F | Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhibition of cAMP production at 100 nM incubated for 15 mins by competitive enzyme-linked immunoassay relative to control | Homo sapiens | 24 | ALA4359861 | cell-based format | Scientific Literature | |
19. | ALA4362018 | F | Antagonist activity at human P2Y14R stably expressed in human forskolin treated THP1 cells assessed as reduction in P2Y14R agonist UDPG-induced inhibition of cAMP production incubated for 15 mins by competitive enzyme-linked immunoassay | Homo sapiens | 24 | ALA4359861 | cell-based format | Scientific Literature | |
20. | ALA4362019 | F | Inhibition of P2Y14 in human THP1 cells assessed as reversal of MSU-induced reduction in cAMP production at 5 to 20 uM pretreated for 1 hr followed by MSU treatment and measured after 12 hrs by ELISA | Homo sapiens | 1 | ALA4359861 | cell-based format | Scientific Literature |