| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA905953 | F | Antagonist activity at mouse CXCR3 by [35S]GTP-gamma-S binding assay | Mus musculus | 1 | ALA1143784 | assay format | Scientific Literature | |
| 2. | ALA928754 | F | Antagonist activity at mouse CXCR3 | Mus musculus | 14 | ALA1140788 | assay format | Scientific Literature | |
| 3. | ALA950215 | B | Displacement of [125I]-CXCL10 from mouse CXCR3 expressed in CHO cell membrane | Mus musculus | 13 | ALA1143901 | cell-based format | Scientific Literature | |
| 4. | ALA1010869 | F | Antagonist activity at mouse recombinant CXCR3 expressed in human U2OS cells | Mus musculus | 13 | ALA1139268 | cell-based format | Scientific Literature | |
| 5. | ALA1046683 | B | Displacement of [125I]I-TAC from mouse CXCR3 expressed in CHO cells by scintillation proximity assay | Mus musculus | 1 | ALA1154177 | cell-based format | Scientific Literature | |
| 6. | ALA1046685 | F | Antagonist activity at mouse CXCR3 expressed in L1.2 cells assessed as inhibition of I-TAC-induced Ca2+ mobilization by FLIPR assay | Mus musculus | 1 | ALA1154177 | cell-based format | Scientific Literature | |
| 7. | ALA1042709 | B | Displacement of ITAC from CXCR3 receptor in mouse whole blood assay | Mus musculus | 1 | ALA1155298 | tissue-based format | Scientific Literature | |
| 8. | ALA1104174 | B | Displacement of [125I]-IP10 from mouse CXCR3 expressed in human PBMC after 2 hrs in RPMI buffer by scintillation counting | Mus musculus | 1 | ALA1153804 | assay format | Scientific Literature | |
| 9. | ALA1687491 | F | Antagonist activity at mouse CXCR3 | Mus musculus | 4 | ALA1681635 | assay format | Scientific Literature | |
| 10. | ALA1810321 | F | Antagonist activity at mouse CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay | Mus musculus | 34 | ALA1806382 | cell-based format | Scientific Literature | |
| 11. | ALA1941427 | B | Receptor occupancy of CXCR3 in mouse whole blood assessed as inhibition of ITAC binding by fluorescence quenching based FACS analysis | Mus musculus | 2 | ALA1938274 | single protein format | Scientific Literature | |
| 12. | ALA5129984 | F | Antagonist activity at recombinant mouse CXCR3 expressed in human CHO-K1 cells co-expressing Galpha15 incubated for 10 mins by Fluo-4AM dye based FLIPR assay | Mus musculus | 1 | ALA5126607 | cell-based format | Scientific Literature | |
| 13. | ALA5251578 | B | Antagonist activity at mouse CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary mouse T cells assessed as inhibition of CXCLI1 mediated cell migration incubated for 45 mins by Boyden chamber assay | Mus musculus | 1 | ALA5247653 | cell-based format | Scientific Literature | |
| 14. | ALA5251583 | B | Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR method | Mus musculus | 1 | ALA5247653 | cell-based format | Scientific Literature | |
| 15. | ALA5251584 | B | Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR method | Mus musculus | 1 | ALA5247653 | cell-based format | Scientific Literature | |
| 16. | ALA5251591 | B | Antagonist activity at CXCR3 in DBA/1 mouse whole blood assessed as receptor internalization incubated for 30 mins in presence of CXCL10 by flow cytometric analysis | Mus musculus | 1 | ALA5247653 | tissue-based format | Scientific Literature | |
| 17. | ALA5251606 | F | In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.006 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry | Mus musculus | 1 | ALA5247653 | organism-based format | Scientific Literature | |
| 18. | ALA5251607 | F | In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.02 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry | Mus musculus | 1 | ALA5247653 | organism-based format | Scientific Literature | |
| 19. | ALA5251608 | F | In vivo antagonist activity at CXCR3 in LPS-induced DBA/1 mouse model assessed as reduction in mouse CXCL10-mediated chemotaxis in CD8+ T cells at 0.06 microg/g, po bid preincubated for 3 days followed by LPS stimulation for 30 mins and measured after 3 days by flow cytometry | Mus musculus | 1 | ALA5247653 | organism-based format | Scientific Literature | |
| 20. | ALA5257197 | B | Antagonist activity at mouse CXCR3 assessed as reduction in CXCL11 induced calcium flux by [35S]GTPgammaS binding assay | Mus musculus | 2 | ALA5257017 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!