# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1932587 | F | Agonist activity at mouse FXR expressed in HEK293 cells co-expressing mouse RXRalpha and ECRE-luc by luciferase reporter gene assay | Mus musculus | 3 | cell-based format | Scientific Literature | ||
2. | ALA1932589 | F | Agonist activity at mouse FXR expressed in HEK293 cells co-expressing mouse RXRalpha and ECRE-luc up to 100 uM by luciferase reporter gene assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
3. | ALA980676 | F | Agonist activity at mouse chimeric FXR assessed as receptor transactivation by luciferase transcriptional reporter gene assay | Mus musculus | 12 | assay format | Scientific Literature | ||
4. | ALA980677 | F | Agonist activity at mouse chimeric FXR assessed as receptor transactivation by luciferase transcriptional reporter gene assay relative to GW-4064 | Mus musculus | 12 | assay format | Scientific Literature | ||
5. | ALA1070844 | F | Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
6. | ALA1070848 | F | Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assay relative to GW-4064 | Mus musculus | 6 | cell-based format | Scientific Literature | ||
7. | ALA3269772 | B | Agonist activity at FXR in mouse primary hepatocytes assessed as upregulation of BESP mRNA expression | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA3830384 | B | Induction of FXR-mediated Akt-phosphorylation at S473 site in serum-starved wild-type mouse primary hepatocytes at 10 uM measured after 10 mins by western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
9. | ALA3830385 | B | Induction of FXR-mediated Akt-phosphorylation at S473 site in serum-starved wild-type mouse primary hepatocytes at 100 uM measured after 10 mins by western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
10. | ALA3830388 | B | Induction of FXR-mediated Akt-phosphorylation in serum-starved wild-type mouse primary hepatocytes assessed as increase in GSK-3beta phosphorylation at 10 uM measured after 10 mins by western blot analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
11. | ALA3830389 | B | Induction of FXR-mediated Akt-phosphorylation in serum-starved wild-type mouse primary hepatocytes assessed as increase in GSK-3beta phosphorylation at 100 uM measured after 10 mins by western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
12. | ALA4009819 | B | Antagonist activity at FXR in C57BL/6 mouse primary hepatocytes assessed as inhibition of Shp mRNA level at 2 uM after 24 hrs by qRT-PCr method | Mus musculus | 2 | cell-based format | Scientific Literature | ||
13. | ALA4009820 | B | Antagonist activity at FXR in C57BL/6 mouse primary hepatocytes assessed as Shp mRNA level at 4 uM after 24 hrs by qRT-PCR method relative to control (Rvb = 0.870425 to 1.118845 No_unit) | Mus musculus | 2 | cell-based format | Scientific Literature | ||
14. | ALA4374501 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Hspb8 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
15. | ALA4374502 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Plaur gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
16. | ALA4374503 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Lpin2 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
17. | ALA4374504 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Slc48a1 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
18. | ALA4374505 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Akr1c13 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
19. | ALA4374506 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Cxcl3 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature | ||
20. | ALA4374507 | B | Allosteric modulation of FXR in wild type mouse liver organoids assessed as log(2) fold change in Rnf152 gene expression at 50 uM after 8 hrs by Heat map RNA sequencing data based analysis relative to control | Mus musculus | 1 | subcellular format | Scientific Literature |