| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2114869 | F | PubChem BioAssay. Turbidimetric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) | 6 | biochemical format | PubChem BioAssays | |||
| 2. | ALA2114758 | F | PubChem BioAssay. Fluorescence Readout Insulin Aggregation Assay to confirm inhibitors of Protein Disulfide Isomerase (Orthogonal Assay) Measured in Biochemical System Using Plate Reader - 2137-03_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) | 5 | biochemical format | PubChem BioAssays | |||
| 3. | ALA1964080 | F | PUBCHEM_BIOASSAY: Turbidimetric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | 108 | biochemical format | PubChem BioAssays | |||
| 4. | ALA2114805 | F | PubChem BioAssay. Turbidimetric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) | 108 | biochemical format | PubChem BioAssays | |||
| 5. | ALA2114826 | F | PubChem BioAssay. Cytotoxicity (24 hours) Measured in Cell-Based System Using Plate Reader - 2137-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | 137 | cell-based format | PubChem BioAssays | |||
| 6. | ALA950409 | B | Binding affinity to disulfide isomerase in human Jurkat cells at 10 uM after 24 hrs by 2D electrophoresis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA3215127 | B | PubChem BioAssay. Turbidometric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_Dose_DryPowder_Activity_Set2. (Class of assay: confirmatory) | 29 | biochemical format | PubChem BioAssays | |||
| 8. | ALA3738071 | B | Binding affinity to PDI catalytic domain a (unknown origin) after 1 hrs by intrinsic tryptophan fluorescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3738074 | B | Irreversible binding affinity to PDI catalytic domain a (unknown origin) at 4.5 mM measured after 100 fold dilution for 2 hrs by intrinsic tryptophan fluorescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3738075 | B | Irreversible binding affinity to PDI catalytic domain a (unknown origin) at 3 mM measured after 100 fold dilution for 2 hrs by intrinsic tryptophan fluorescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4119044 | B | Binding affinity to P4HB in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4257297 | B | Inhibition of recombinant human PDI expressed in Escherichia coli assessed as reduction in enzyme-mediated bovine insulin aggregation after 30 mins by turbidimetric assay | Homo sapiens | 14 | assay format | Patent Bioactivity Data | ||
| 13. | ALA4257304 | B | Inhibition of PDI in human platelet rich plasma assessed as reduction in SFLLRN peptide-induced platelet aggregation preincubated for 30 mins followed by SFLLRN addition relative to control | Homo sapiens | 4 | assay format | Patent Bioactivity Data | ||
| 14. | ALA4321231 | B | Binding affinity to recombinant human His-tagged PDI (18 to 479 residues) expressed in Escherichia coli assessed as melting temperature at 20 uM by SYPRO orange protein gel staining based differential scanning fluorimetry (Rvb = 58.86 +/- 0.12 degreeC) | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 15. | ALA4390738 | B | Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bovine insulin aggregation | Homo sapiens | 72 | assay format | Scientific Literature | ||
| 16. | ALA4390753 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 17. | ALA4390754 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as increase in melting temperature by ROX dye based thermal shift assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 18. | ALA4390755 | B | Binding affinity to recombinant human N-terminal His-tagged PDI H256A mutant expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 19. | ALA4390756 | B | Binding affinity to recombinant human N-terminal His-tagged PDI C53S/C397S double mutant expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 20. | ALA4390757 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS by ROX dye based thermal shift assay | Homo sapiens | 1 | assay format | Scientific Literature |
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