# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1961842 | B | Effect on CAR(NR1I3) dependent reporter activity in HEK293 cells at 20 uM | 2 | cell-based format | Scientific Literature | |||
2. | ALA951425 | B | Inhibition of human CAR | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA941272 | B | Activation of human CAR-LBD expressed in human C3A cells at 10 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
4. | ALA941273 | B | Activation of human CAR-LBD expressed in human C3A cells at 4 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA941274 | B | Activation of human CAR Phe161Ala mutant expressed in human C3A cells at 10 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
6. | ALA941275 | B | Activation of human CAR Phe161Ala mutant expressed in human C3A cells at 4 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA941276 | B | Activation of human CAR Ile164Ala mutant expressed in human C3A cells at 10 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
8. | ALA941277 | B | Activation of human CAR Ile164Ala mutant expressed in human C3A cells at 4 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA948392 | B | Activation of human CAR Asn165Ala mutant expressed in human C3A cells at 4 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA948393 | B | Activation of human CAR His203Ala mutant expressed in human C3A cells at 10 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
11. | ALA948394 | B | Activation of human CAR His203Ala mutant expressed in human C3A cells at 4 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA948401 | B | Increase in human steroid receptor coactivator 1 binding to human CAR-LBD expressed in human C3A cells by mammalian two-hybrid assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
13. | ALA948402 | B | Increase in human nuclear co-repressor receptor binding to human CAR-LBD expressed in HEK293 cells by yeast two-hybrid assay | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
14. | ALA952306 | B | Activation of human CAR Asn165Ala mutant expressed in human C3A cells at 10 uM after 24 hrs by GAL4-dependent luciferase reporter gene assay relative to control | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
15. | ALA1211340 | F | Agonist activity at CAR-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assay | 3 | cell-based format | Scientific Literature | |||
16. | ALA1211357 | F | Agonist activity at CAR-LBD expressed in HEK293 cells assessed as Gal4-DBD interaction by cellular mammalian one hybrid assay relative to androstane | 3 | cell-based format | Scientific Literature | |||
17. | ALA1743254 | A | Constitutive androstane receptor indirect activator | Homo sapiens | 2 | single protein format | Scientific Literature | ||
18. | ALA1743246 | A | Constitutive androstane receptor inverse agonist | Homo sapiens | 2 | single protein format | Scientific Literature | ||
19. | ALA3385873 | B | Agonist activity at human CAR expressed in HEK293 cells by luciferase reporter gene assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA3532959 | A | Antagonist activity at human CAR expressed in human HepG2 cells coexpressing CYP2B6 assessed as inhibition of CITCO-induced receptor activation up to 100 uM after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature |