# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3777120 | Binding | Inhibition of recombinant GGDPS (unknown origin) assessed as radiolabeled GGPP formation preincubated for 10 mins followed by addition of 10 uM FPP substrate and [14C]IPP for 30 mins by liquid scintillation counter analysis | Homo sapiens | 4 | ALA3774363 | single protein format | Scientific Literature | |
2. | ALA3777123 | Binding | Inhibition of GGDPS in human RPMI8226 cells assessed as disruption of Rap1a geranylation after 48 hrs by immunoblot analysis | Homo sapiens | 3 | ALA3774363 | cell-based format | Scientific Literature | |
3. | ALA3777124 | Binding | Inhibition of GGDPS in human RPMI8226 cells assessed as disruption of Rap1a geranylation at 50 nM after 48 hrs by ELISA | Homo sapiens | 1 | ALA3774363 | cell-based format | Scientific Literature | |
4. | ALA3820525 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as disruption of Rap1a geranylgeranylation after 48 hrs by immunoblot analysis | Homo sapiens | 5 | ALA3817777 | cell-based format | Scientific Literature | |
5. | ALA3820526 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as lambda light chain levels after 48 hrs by ELISA | Homo sapiens | 5 | ALA3817777 | cell-based format | Scientific Literature | |
6. | ALA3820530 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as disruption of Rap1a geranylgeranylation at 5 uM after 48 hrs by immunoblot analysis in presence of GGDP | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
7. | ALA3820531 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as lambda light chain levels at 5 uM after 48 hrs by ELISA in presence of GGDP | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
8. | ALA3820532 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as disruption of Rap1a geranylgeranylation at 5 uM after 48 hrs by immunoblot analysis in presence of mevalonate | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
9. | ALA3820533 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as lambda light chain levels at 5 uM after 48 hrs by ELISA in presence of mevalonate | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
10. | ALA3820534 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as disruption of Rap1a geranylgeranylation at 1 uM after 48 hrs by immunoblot analysis in presence of GGDP | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
11. | ALA3820535 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as lambda light chain levels at 1 uM after 48 hrs by ELISA in presence of GGDP | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
12. | ALA3820696 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as disruption of Rap1a geranylgeranylation at low concentrations after 48 hrs by immunoblot analysis | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
13. | ALA3820697 | Binding | Inhibition of GGDPS in human RPMI8266 cells assessed as lambda light chain levels at low concentrations after 48 hrs by ELISA | Homo sapiens | 1 | ALA3817777 | cell-based format | Scientific Literature | |
14. | ALA681671 | Binding | Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase). | 29 | ALA1135417 | single protein format | Scientific Literature | ||
15. | ALA886672 | Binding | Inhibition of FTase at 100 uM | Homo sapiens | 16 | ALA1139158 | single protein format | Scientific Literature | |
16. | ALA1110033 | Binding | Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation counting | 4 | ALA1157780 | single protein format | Scientific Literature | ||
17. | ALA1110036 | Binding | Inhibition of GGPPS at 1mM after 10 mins using [14C]IPP as substrate by liquid scintillation counting | 1 | ALA1157780 | single protein format | Scientific Literature | ||
18. | ALA1250623 | Binding | Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria at 10 uM by liquid scintillation counting | Homo sapiens | 7 | ALA1250542 | assay format | Scientific Literature | |
19. | ALA1250629 | Binding | Inhibition of GGDPS in human K562 cells assessed as reduction Rap1a protein geranylgeranylation after 48 hrs by Western blotting in presence GGPP | Homo sapiens | 2 | ALA1250542 | cell-based format | Scientific Literature | |
20. | ALA1250630 | Binding | Inhibition of GGDPS in human K562 cells assessed as reduction Rab6 protein geranylgeranylation after 48 hrs by Western blotting in presence GGPP | Homo sapiens | 2 | ALA1250542 | cell-based format | Scientific Literature |