| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1023797 | B | Binding affinity to mouse P2X7 channel | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 2. | ALA1048351 | B | Binding affinity at mouse P2X7 receptor | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 3. | ALA1780726 | F | Antagonist activity at P2X7 receptor in mouse LPS-stimulated peritoneal macrophages assessed as inhibition of ATP-induced IL1-beta release at 10 uM by ELISA | Mus musculus | 1 | assay format | Scientific Literature | ||
| 4. | ALA2344145 | B | Antagonist activity at mouse P2X7 receptor assessed as inhibition of ATP-induced Ca2+ flux by FLIPR assay | Mus musculus | 2 | single protein format | Scientific Literature | ||
| 5. | ALA3418723 | B | Antagonist activity at P2X7 receptor in LPS-primed mouse J774.A1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA3858377 | B | Antagonist activity at recombinant mouse P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux preincubated for 30 mins followed by agonist addition measured after 180 sec by calcium-4 dye based FLIPR assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA3858388 | B | Antagonist activity at P2X7 receptor in LPS-stimulated mouse whole blood assessed as inhibition of Bz-ATP-induced IL-1beta release incubated for 30 mins after LPS stimulation for 1 hr followed by agonist addition measured after 1.5 hrs by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA3859177 | B | Antagonist activity at mouse P2X7 receptor assessed as reduction in calcium flux by FLIPR calcium flux assay | Mus musculus | 9 | single protein format | Scientific Literature | ||
| 9. | ALA3859179 | B | Antagonist activity at P2X7 receptor in C57/bl6 mouse whole blood assessed as reduction in LPS/BzATP-induced IL-1beta release preincubated with LPS-stimulated cells for 30 mins followed by BzATP addition measured after 1.5 hrs by ELISA | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
| 10. | ALA4012088 | B | Antagonist activity at mouse P2X7 receptor expressed in 1321N1 cells assessed as inhibition of agonist-induced calcium flux pretreated for 3 mins followed by BzATP addition after 3 mins measured every 1 sec for 60 secs and at 5 secs interval throughout testing by Flou-4-AM dye based FLIPR assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4054682 | B | Antagonist activity at P2X7 in mouse whole blood assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP addition measured after 1.5 hrs by ELISA | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4054688 | B | Antagonist activity at mouse P2X7 assessed as inhibition of BzATP-induced calcium flux preincubated for 30 mins followed by BzATP addition measured over 180 secs by FLIPR assay | Mus musculus | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4133142 | B | Antagonist activity at mouse P2X7 receptor expressed in human 1321N1 cells assessed as reduction in agonist-induced intracellular Ca2+ levels preincubated for 3 mins followed by agonist addition measured up to 2 mins by Fluo-4 dye-based FLIPR assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4133148 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake after 25 mins by flow cytometric analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 15. | ALA4133149 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by ATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 16. | ALA4133152 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced ethidium iodide uptake after 30 mins by spectrofluorometric analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4133153 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by BzATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4133155 | B | Antagonist activity at P2X7 receptor in LPS/IFNc-differentiated Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 30 mins followed by LPS stimulation for 4 hrs using cells treated with ATP for 15 mins by ELISA | Mus musculus | 2 | assay format | Scientific Literature | ||
| 19. | ALA4133197 | B | Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake at 10 uM preincubated for 10 mins followed by ATP addition measured after 20 mins by FLIPR assay relative to 1 mM ATP | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 20. | ALA4219900 | B | Agonist activity at P2X7 receptor in C57Bl6 mouse lumbar spinal cord slices assessed as increase in glycinergic inhibitory postsynaptic currents after 20 to 26 mins by electrophysiology method relative to control | Mus musculus | 1 | single protein format | Scientific Literature |
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