| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2090464 | A | Hydrolytic stability of the compound assessed as human NPP3-mediated hydrolysis after 3 hrs by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 2. | ALA1805828 | B | Activity of human NPP3 expressed in COS7 cells assessed as production of p-nitrophenol using Ap5A as the substrate at 100 uM after 30 mins by malachite green reagent method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA1806212 | B | Inhibition of human NPP3 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate at 100 uM after 15 mins by malachite green reagent method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA1806213 | B | Inhibition of human NPP3 expressed in COS7 cells assessed as production of p-nitrophenol using Ap5A as the substrate at 100 uM after 30 mins by malachite green reagent method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA1806214 | B | Inhibition of human NPP3 expressed in COS7 cells assessed as amount of inorganic phosphate released using ATP as the substrate at 100 uM after 15 mins by malachite green reagent method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA1004222 | B | Activity of human NPP3 expressed in human 293T cells assessed as drug hydrolysis at 100 uM after 20 mins by reverse-phase HPLC relative to p-nitrophenyl-thymidine-5-monophosphate | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA1005038 | B | Inhibition of human NPP3 expressed in human 293T cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA2390591 | A | Drug metabolism assessed as human nucleotide pyrophosphatase/phosphodiesterase3-mediated compound hydrolysis at 4.24 mM after 1 hr by HPLC analysis relative to ADP | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA3089666 | B | Inhibition of NPP3 in human HTB-85 cells assessed as production of p-nitrophenol using pnp-TMP at 100 uM measured after 20 mins by spectrophotometry | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA3089711 | B | Inhibition of human NPP3 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate preincubated at 100 uM for 3 mins before substrate addition measured after 15 mins by HPLC analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA3293339 | A | Drug metabolism assessed as human NPP3-mediated compound hydrolysis expressed in African green monkey COS7 cells at 100 uM after 1 hr by HPLC analysis relative to ATP | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA3293345 | A | Drug metabolism assessed as human NPP3-mediated compound hydrolysis expressed in African green monkey COS7 cells at 100 uM after 1 hr by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA3293350 | B | Inhibition of human NPP3 using pNP-TMP as substrate at 100 uM after 20 mins by reversed-phase HPLC analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 14. | ALA3384857 | B | Competitive inhibition of human NPP3 using ATP as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 15. | ALA3607672 | A | Drug metabolism assessed as human NPP3-mediated compound hydrolysis at 100 uM after 3 hrs by HPLC analysis relative to UDP-treated control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA3607675 | B | Inhibition of human NPP3-mediated UDP hydrolysis at 100 uM after 3 hrs relative to UDP-treated control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 17. | ALA3635195 | A | Drug metabolism assessed as human eNPP3-mediated compound hydrolysis at 4 mM after 3 hrs by reverse-phase HPLC analysis relative to ATP | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA3635197 | A | Drug metabolism assessed as human eNPP3-mediated compound hydrolysis after 3 hrs by reverse-phase HPLC analysis relative to ATP | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 19. | ALA3815630 | B | Inhibition of human recombinant NPP3 expressed in insect SF9 cells using ATP as substrate at >100 uM preincubated with substrate followed by protein addition and subsequent incubation for 60 mins by capillary electrophoresis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4131383 | B | Inhibition of human full length NPP3 expressed in African green monkey COS7 cell membrane fraction using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins | Homo sapiens | 14 | assay format | Scientific Literature |
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